RTN4 and HLA-DPB1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		RTN4	HLA-DPB1
Description		reticulon 4	major histocompatibility complex, class II, DP beta 1
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GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane	Golgi Membrane Lysosomal Membrane Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Cadherin Binding	Protein Binding MHC Class II Protein Complex Binding Peptide Antigen Binding
	Biological Process	Blastocyst Formation Apoptotic Process Axonal Fasciculation Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia-guided Migration Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Regulation Of Apoptotic Process Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Protein Kinase B Signaling Cardiac Epithelial To Mesenchymal Transition Protein Localization To Lysosome Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Cellular Sphingolipid Homeostasis Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve	Adaptive Immune Response Immunoglobulin Production Involved In Immunoglobulin-mediated Immune Response Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation
Pathways		Axonal growth inhibition (RHOA activation)	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs
Diseases
GWAS		Adult body size ( 32376654) Fasting glucose ( 34074324) Lymphocyte counts ( 32888494) Obesity (extreme) ( 19553259) Platelet count ( 32888494) Systolic blood pressure ( 30224653 32902719)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Alanine aminotransferase levels ( 34315874) Anti-rubella virus IgG levels ( 30053915) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Aspartate aminotransferase levels ( 34315874) Aspirin exacerbated respiratory disease in asthmatics ( 23180272) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Chronic hepatitis B infection ( 24940741 25802187) Dermatomyositis ( 27153935) EGFR mutation-positive lung adenocarcinoma ( 27501781) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Extranodal natural killer T-cell lymphoma (nasal type) ( 27470079) Gait speed in old age ( 28077804) Hepatitis B ( 21750111 33736632 19349983) Hepatitis B (viral clearance) ( 22737229) Hepatitis B vaccine response ( 21764829) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Monocyte count ( 32888494 27863252) Myositis ( 26291516) Nephropathy ( 21399633) Neutrophil count ( 32888494) Nodular sclerosis Hodgkin lymphoma ( 29196614) Persistent hepatitis B virus infection ( 27244555 33736632) Plantar warts ( 28928442) Primary biliary cholangitis ( 28425483) Pulmonary arterial hypertension ( 30527956) Response to hepatitis B vaccine ( 31243853 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Severe aplastic anemia ( 32004448) SjÃ¶gren's syndrome ( 24097066 28076899) Systemic sclerosis ( 21779181) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Wegener's granulomatosis ( 23740775) White blood cell count ( 32888494) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		55 interacting genes: BAIAP2 BCL2 BCL2L1 BDKRB1 CCR4 CERT1 CGREF1 CHMP6 CHRM4 CLN8 CNTNAP1 CRMP1 CYSLTR2 DRD2 ERBB2 ERBB3 ERBB4 F2RL1 FXR2 GLP1R GPR35 HLA-DPB1 HTR2C IPP LAMA4 LINC01554 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 NRXN1 NSD1 OGT PLEKHF2 POT1 PPP1R21 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 STON1 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21	9 interacting genes: CD74 COPB1 HLA-DPA1 HLA-DQA1 LZTS2 MEOX2 ROBO2 RTN4 TRIP6
Entrez ID		57142	3115
HPRD ID		07259	00832
Ensembl ID		ENSG00000115310	ENSG00000223865
Uniprot IDs		Q9NQC3	I4EC15 P04440
PDB IDs		2G31 2JV5	3LQZ 4P4K 4P4R 4P57 4P5K 4P5M
Enriched GO Terms of Interacting Partners?
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