GOPC and MYOCD

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		GOPC	MYOCD
Description		golgi associated PDZ and coiled-coil motif containing	myocardin
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Trans-Golgi Network Transport Vesicle Dendrite Golgi-associated Vesicle Membrane Protein-containing Complex	Chromatin Nucleus
	Molecular Function	Protein Binding Identical Protein Binding Transmembrane Transporter Binding	Transcription Coactivator Activity Protein Binding Histone Acetyltransferase Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding DNA-binding Transcription Factor Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Negative Regulation Of Anion Channel Activity Protein Transport Cytoplasmic Sequestering Of CFTR Protein Apical Protein Localization Negative Regulation Of Protein Localization To Cell Surface	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth By Extracellular Stimulus Vasculogenesis Response To Hypoxia Cardiac Ventricle Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiocyte Differentiation Regulation Of Histone Acetylation Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of DNA Binding Cellular Component Maintenance Regulation Of Myoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Lung Alveolus Development Digestive Tract Development Positive Regulation Of DNA-binding Transcription Factor Activity Smooth Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Uterus Development Urinary Bladder Development Negative Regulation Of Cell Adhesion Molecule Production Ductus Arteriosus Closure Negative Regulation Of Amyloid-beta Clearance Regulation Of Phenotypic Switching Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways		RHO GTPases regulate CFTR trafficking RHOQ GTPase cycle
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Colorectal cancer ( 23266556) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Night sleep phenotypes ( 27126917)	Atrial fibrillation ( 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) PR interval ( 30679814 30046033 32439900) QRS duration ( 31251759) Systolic blood pressure change trajectory ( 27980656) Testosterone levels ( 22675492)
Interacting Genes		71 interacting genes: ABCA1 ADRB1 AKIRIN1 ASIC3 ATG9A BATF BECN1 C17orf67 CCDC102B CCDC198 CD300C CDKN2C CERCAM CFTR CLCN3 CRHR1 CSPG5 DLEU1 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GEM GOLGA3 GRID1 GRID2 HCK HNRNPLL IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MYLK MYOCD NOTCH1 NUP62 OSBP2 PARK7 PID1 PPP1R18 PWWP3A RALGAPB RELA RHOQ RNF183 RNF220 RPL13AP17 RPS6KA1 RTKN SEMA4G SLC25A18 SNX31 SPATA8 SSTR5 STARD3 STX6 TGFBR2 TUBE1 VIM VTN ZBTB49 ZDHHC1 ZNF564 ZNF581 ZNF587 ZNF835 ZSCAN1	12 interacting genes: GOPC GSK3B KDM3A MAMSTR MRTFA MYOD1 NFATC3 SMAD2 SMAD3 SMARCA4 SRF STUB1
Entrez ID		57120	93649
HPRD ID		06024	09362
Ensembl ID		ENSG00000047932	ENSG00000141052
Uniprot IDs		Q9HD26	Q8IZQ8
PDB IDs		2DC2 2LOB 4E34 4E35 4JOE 4JOF 4JOG 4JOH 4JOJ 4JOK 4JOP 4JOR 4K6Y 4K72 4K75 4K76 4K78 4NMO 4NMP 4NMQ 4NMR 4NMS 4NMT 4NMV 4Q6H 4Q6S 5IC3 5K4F 6OV7 6V84 6XNJ
Enriched GO Terms of Interacting Partners?
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