MYOCD and MAMSTR

Number of citations of the paper that reports this interaction (PubMedID 16818234)
49

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		MYOCD	MAMSTR
Description		myocardin	MEF2 activating motif and SAP domain containing transcriptional regulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus
	Molecular Function	Transcription Coactivator Activity Protein Binding Histone Acetyltransferase Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding DNA-binding Transcription Factor Binding	Transcription Coregulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth By Extracellular Stimulus Vasculogenesis Response To Hypoxia Cardiac Ventricle Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiocyte Differentiation Regulation Of Histone Acetylation Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of DNA Binding Cellular Component Maintenance Regulation Of Myoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Lung Alveolus Development Digestive Tract Development Positive Regulation Of DNA-binding Transcription Factor Activity Smooth Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Uterus Development Urinary Bladder Development Negative Regulation Of Cell Adhesion Molecule Production Ductus Arteriosus Closure Negative Regulation Of Amyloid-beta Clearance Regulation Of Phenotypic Switching Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Myotube Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) PR interval ( 30679814 30046033 32439900) QRS duration ( 31251759) Systolic blood pressure change trajectory ( 27980656) Testosterone levels ( 22675492)	Alcohol use disorder (total score) ( 30336701) Apolipoprotein A1 levels ( 33730874) Bipolar disorder ( 21926972) Blood urea nitrogen levels ( 31152163) Childhood asthma with severe exacerbations ( 33328473) Cooked vegetable consumption ( 32066663) Crohn's disease ( 28067908) Dentures ( 31235808) Estimated glomerular filtration rate ( 31152163 31451708) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Meat-related diet ( 32066663) Mitochondrial heteroplasmy measurement ( 33731350) Multiple sclerosis ( 21833088) Non-oily fish consumption ( 32066663) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Pubertal anthropometrics ( 23449627) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		12 interacting genes: GOPC GSK3B KDM3A MAMSTR MRTFA MYOD1 NFATC3 SMAD2 SMAD3 SMARCA4 SRF STUB1	1 interacting genes: MYOCD
Entrez ID		93649	284358
HPRD ID		09362	08204
Ensembl ID		ENSG00000141052	ENSG00000176909
Uniprot IDs		Q8IZQ8	Q6ZN01
PDB IDs
Enriched GO Terms of Interacting Partners?
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