PYY and NPY2R

Number of citations of the paper that reports this interaction (PubMedID 11408607)
12

Data Source:
HPRD (in vitro)

		PYY	NPY2R
Description		peptide YY	neuropeptide Y receptor Y2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Cilium Non-motile Cilium
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Neuropeptide Y Receptor Binding	Peptide YY Receptor Activity Neuropeptide Y Receptor Activity Calcium Channel Regulator Activity Protein Binding Signaling Receptor Activity
	Biological Process	Neuropeptide Signaling Pathway Feeding Behavior Intestinal Epithelial Cell Differentiation	Behavioral Fear Response Positive Regulation Of Peptide Secretion Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Nitric Oxide Mediated Signal Transduction Aging Locomotory Behavior Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Nervous System Process Positive Regulation Of Dopamine Secretion Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Secretion Negative Regulation Of Secretion Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Excitatory Postsynaptic Potential Negative Regulation Of Feeding Behavior
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Cysteamine Peptide YY (3-36) Obinepitide
Diseases
GWAS		Blood protein levels ( 30072576) Diverticular disease ( 30177863) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Pulse pressure ( 28135244) Response to taxane treatment (placlitaxel) ( 23006423) Triglyceride levels ( 32203549)	Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Premature menopause in childhood cancer survivors ( 29432556)
Interacting Genes		6 interacting genes: MEP1B NPY1R NPY2R NPY4R NPY5R SGTA	4 interacting genes: NPY PYY RGS12 TRARG1
Entrez ID		5697	4887
HPRD ID		02869	01216
Ensembl ID		ENSG00000131096	ENSG00000185149
Uniprot IDs		P10082	P49146
PDB IDs		2DEZ 2DF0 2L60 2NA5	2IK3
Enriched GO Terms of Interacting Partners?
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