LHX9 and LDB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LHX9	LDB1
Description		LIM homeobox 9	LIM domain binding 1
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GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cell Leading Edge Protein-containing Complex Beta-catenin-TCF Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Transcription Coregulator Activity Protein Binding Enzyme Binding LIM Domain Binding Protein Homodimerization Activity Protein Self-association RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Male Gonad Development Female Gonad Development Neuron Differentiation Gonad Morphogenesis Negative Regulation Of Transcription, DNA-templated Dorsal Spinal Cord Interneuron Anterior Axon Guidance	Negative Regulation Of Transcription By RNA Polymerase II Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Multicellular Organism Development Nervous System Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of Cell Migration Regulation Of Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Mesendoderm Development Regulation Of Focal Adhesion Assembly
Pathways		Regulation of expression of SLITs and ROBOs	RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549)	General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Pulse pressure ( 30578418)
Interacting Genes		9 interacting genes: CSNK2A1 CWF19L2 IGFN1 KHK LDB1 LDB2 SMAD2 SMURF1 UBTFL1	34 interacting genes: ARTN ATXN1 CTDSP1 DNMT3L ESR1 IDI2 IRAK3 ISL1 ISL2 LHX1 LHX2 LHX3 LHX4 LHX6 LHX8 LHX9 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP UPF1
Entrez ID		56956	8861
HPRD ID		07299	09144
Ensembl ID		ENSG00000143355	ENSG00000198728
Uniprot IDs		H0YL54 Q9NQ69	A0A6E1WJ75 Q86U70
PDB IDs		2DMQ	2XJY 2XJZ 2YPA 6TYD
Enriched GO Terms of Interacting Partners?
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