LXN and FCGR3A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LXN	FCGR3A
Description		latexin	Fc fragment of IgG receptor IIIa
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Metalloendopeptidase Inhibitor Activity Heparin Binding	Transmembrane Signaling Receptor Activity IgG Binding
	Biological Process	Inflammatory Response Negative Regulation Of Endopeptidase Activity Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain	Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Immune Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs			Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Alefacept Palivizumab Daclizumab Bevacizumab Catumaxomab Sarilumab Benralizumab
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143)	Alanine aminotransferase levels ( 33547301) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758) Blood protein levels ( 28240269) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Hematocrit ( 32888494) Hemoglobin ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Monocyte percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 30498034 23830517) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908)
Interacting Genes		25 interacting genes: BOC CA3 COX6A1 CYBC1 DNAJC11 DPYD FCGR3A GSG1L IGSF11 MAGEA8 MCMDC2 NSMF PAX6 PPP1R3C RNF4 SHKBP1 SPAG7 TMEM14A TRAIP TRIM39 YIF1B ZCCHC17 ZKSCAN4 ZNF430 ZNF679	20 interacting genes: APCS APP CD247 CD38 CD4 FCER1G FCGR1A FCGR2A GP6 IGHG1 LCK LXN PRKCA PRKCI PTPRC S100A4 SHC1 SYK ZAP70 ZBTB25
Entrez ID		56925	2214
HPRD ID		14327	00903
Ensembl ID		ENSG00000079257	ENSG00000203747
Uniprot IDs		Q9BS40	H0Y755 P08637
PDB IDs		2BO9	3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5VU0 5XJE 5XJF 5YC5
Enriched GO Terms of Interacting Partners?
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