PSD and GNB5

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		PSD	GNB5
Description		pleckstrin and Sec7 domain containing	G protein subunit beta 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cleavage Furrow Ruffle Membrane Dendritic Spine Extrinsic Component Of Postsynaptic Endosome Membrane Postsynaptic Density, Intracellular Component	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Presynapse GTPase Activator Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phospholipid Binding	GTPase Activity GTPase Activator Activity Protein Binding Signaling Receptor Complex Adaptor Activity G-protein Gamma-subunit Binding Chaperone Binding
	Biological Process	Signal Transduction Neuron Projection Development Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity	Signal Transduction G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Light Adaption Positive Regulation Of GTPase Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Dark Adaptation
Pathways			Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Lewy body disease ( 25188341)
Interacting Genes		5 interacting genes: GLRA2 GMFG GNB5 HEXD RAB40C	27 interacting genes: ANXA7 APP BNIP3L CDKN1A CSNK2B DRD2 E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1
Entrez ID		5662	10681
HPRD ID		09085	09191
Ensembl ID		ENSG00000059915	ENSG00000069966
Uniprot IDs		A5PKW4 Q86YI3	A0A024R5R9 A0A024R5V3 O14775
PDB IDs
Enriched GO Terms of Interacting Partners?
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