GNB5 and RGS9

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		GNB5	RGS9
Description		G protein subunit beta 5	regulator of G protein signaling 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Presynapse GTPase Activator Complex	Nucleus Cytoplasm Plasma Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Signaling Receptor Complex Adaptor Activity G-protein Gamma-subunit Binding Chaperone Binding	GTPase Activity GTPase Activator Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Light Adaption Positive Regulation Of GTPase Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Dark Adaptation	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Nervous System Development Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Response To Estradiol Intracellular Signal Transduction Light Adaption Regulation Of Catalytic Activity Positive Regulation Of NMDA Glutamate Receptor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Dark Adaptation
Pathways		Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Lewy body disease ( 25188341)	Adverse response to antithyroid drugs in Graves disease ( 30067105) Heel bone mineral density ( 30598549 28869591)
Interacting Genes		27 interacting genes: ANXA7 APP BNIP3L CDKN1A CSNK2B DRD2 E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1	6 interacting genes: ADRB2 DRD3 GNAT1 GNB5 GUCY2D RGS9BP
Entrez ID		10681	8787
HPRD ID		09191	04962
Ensembl ID		ENSG00000069966	ENSG00000108370
Uniprot IDs		A0A024R5R9 A0A024R5V3 O14775	A8K1G1 O75916
PDB IDs
Enriched GO Terms of Interacting Partners?
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