PRTN3 and F2RL1

Number of citations of the paper that reports this interaction (PubMedID 10978167)
27

Data Source:
HPRD (in vitro, in vivo)

		PRTN3	F2RL1
Description		proteinase 3	F2R like trypsin receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Plasma Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome	Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Pseudopodium
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Serine-type Peptidase Activity Enzyme Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding Signaling Receptor Activity
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Phagocytosis Positive Regulation Of Cell Population Proliferation Antimicrobial Humoral Response Collagen Catabolic Process Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Negative Regulation Of Phagocytosis Neutrophil Extravasation Mature Conventional Dendritic Cell Differentiation	T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Chemokine Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Neutrophil Activation Vasodilation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Eosinophil Degranulation Positive Regulation Of GTPase Activity Innate Immune Response Cell-cell Junction Maintenance Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Defense Response To Virus Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Common Pathway of Fibrin Clot Formation Other interleukin signaling Neutrophil degranulation Antimicrobial peptides	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Elafin
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood protein levels ( 30072576 29875488) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) White blood cell count (basophil) ( 27863252)	Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171)
Interacting Genes		13 interacting genes: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF	84 interacting genes: ABCC8 ABHD14A ADCY2 ANKRA2 ARL6IP1 ATP2A2 ATP2B1 ATP2C1 BSG CANX CAPN1 CAPN2 CAPNS1 CBL CD63 CD81 CLPTM1 CNN3 COPS5 CRLS1 CTNNA1 CTSG CYFIP2 DNMT3L ELANE ERGIC3 F2 F2R GJB6 GJC2 GPRASP1 HERPUD1 HLA-E HMOX2 HSPA1B ICAM2 JMY KDELR1 KLC1 LMNA MAP1B MFSD10 MORN4 NAT14 NBPF15 NUMA1 OSTC P4HTM PCBD2 PHLDA1 PIGU PLG PPM1J PRNP PRRT2 PRTN3 PSMC3 PTDSS2 QSER1 R3HDM1 RAD17 RGR RTN1 RTN4 SCN1B SDHD SLC12A5 SLC18B1 SLC1A4 SLC31A2 SLC32A1 SLC35A1 SLC39A13 SLC43A2 ST14 SYNGR2 TMBIM1 TMED1 TMEM161A TMEM62 TMX2 WFS1 YIPF1 YIPF6
Entrez ID		5657	2150
HPRD ID		01512	02960
Ensembl ID		ENSG00000196415	ENSG00000164251
Uniprot IDs		P24158	P55085
PDB IDs		1FUJ	5NDD 5NDZ 5NJ6
Enriched GO Terms of Interacting Partners?
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