F2RL1 and ABCC8

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		F2RL1	ABCC8
Description		F2R like trypsin receptor 1	ATP binding cassette subfamily C member 8
Image
GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Pseudopodium	Mitochondrion Plasma Membrane Inward Rectifying Potassium Channel Membrane Synaptic Vesicle Membrane Potassium Ion-transporting ATPase Complex Sarcolemma
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding Signaling Receptor Activity	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase-coupled Cation Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Transmembrane Transporter Binding ABC-type Transporter Activity
	Biological Process	T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Chemokine Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Neutrophil Activation Vasodilation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Eosinophil Degranulation Positive Regulation Of GTPase Activity Innate Immune Response Cell-cell Junction Maintenance Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Defense Response To Virus Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Cellular Glucose Homeostasis Potassium Ion Transport Female Pregnancy Memory Visual Learning Response To PH Response To Xenobiotic Stimulus Response To Zinc Ion Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Angiogenesis Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Negative Regulation Of Insulin Secretion Transmembrane Transport Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Wound Healing Negative Regulation Of Neuroblast Migration Cellular Response To Organic Substance Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Uterine Smooth Muscle Relaxation Positive Regulation Of Voltage-gated Potassium Channel Activity Positive Regulation Of Tight Junction Disassembly Negative Regulation Of Blood-brain Barrier Permeability
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias
Drugs			ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine
Diseases
GWAS		Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171)	Academic attainment (English) ( 33594131) Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Two-hour glucose ( 34059833) Type 2 diabetes ( 29632382 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382) Weight ( 34074324)
Interacting Genes		84 interacting genes: ABCC8 ABHD14A ADCY2 ANKRA2 ARL6IP1 ATP2A2 ATP2B1 ATP2C1 BSG CANX CAPN1 CAPN2 CAPNS1 CBL CD63 CD81 CLPTM1 CNN3 COPS5 CRLS1 CTNNA1 CTSG CYFIP2 DNMT3L ELANE ERGIC3 F2 F2R GJB6 GJC2 GPRASP1 HERPUD1 HLA-E HMOX2 HSPA1B ICAM2 JMY KDELR1 KLC1 LMNA MAP1B MFSD10 MORN4 NAT14 NBPF15 NUMA1 OSTC P4HTM PCBD2 PHLDA1 PIGU PLG PPM1J PRNP PRRT2 PRTN3 PSMC3 PTDSS2 QSER1 R3HDM1 RAD17 RGR RTN1 RTN4 SCN1B SDHD SLC12A5 SLC18B1 SLC1A4 SLC31A2 SLC32A1 SLC35A1 SLC39A13 SLC43A2 ST14 SYNGR2 TMBIM1 TMED1 TMEM161A TMEM62 TMX2 WFS1 YIPF1 YIPF6	5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8
Entrez ID		2150	6833
HPRD ID		02960	02741
Ensembl ID		ENSG00000164251	ENSG00000006071
Uniprot IDs		P55085	Q09428
PDB IDs		5NDD 5NDZ 5NJ6	6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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