MASP1 and C2

Number of citations of the paper that reports this interaction (PubMedID 10946292)
56

Data Source:
HPRD (in vitro)

		MASP1	C2
Description		MBL associated serine protease 1	complement C2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytosol	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding	Serine-type Endopeptidase Activity Protein Binding Metal Ion Binding
	Biological Process	Complement Activation, Lectin Pathway Proteolysis	Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors	Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Impulsivity (attentional) ( 30718321) Type 2 diabetes ( 30130595)	Advanced age-related macular degeneration ( 26691988) Age at first sexual intercourse ( 34211149) Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) Circulating myeloperoxidase levels (serum) ( 23620142) Clostridioides difficle infection ( 33841421) Coffee consumption ( 31046077) Coronary artery disease ( 29212778 30104761) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Endometriosis ( 28881265) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Hepatocellular carcinoma ( 21105107) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Platelet aggregation ( 29185836) Prostate cancer ( 23535732) Sulfasalazine-induced agranulocytosis ( 28762467) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		16 interacting genes: C2 C3 FCN2 GADD45A GSK3B H2AX MAPK6 MAPK8IP2 MAPT MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1	15 interacting genes: C3 C4B C5 CREB3 EBP ERGIC3 FAM209A MASP1 MUC1 PSMA4 SEC11C SLC10A1 SLC35C2 STOM TNF
Entrez ID		5648	717
HPRD ID		02749	08939
Ensembl ID		ENSG00000127241	ENSG00000166278
Uniprot IDs		F8W876 P48740	A0A0G2JL69 B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6
PDB IDs		3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD	2I6Q 2I6S 2ODP 2ODQ 3ERB
Enriched GO Terms of Interacting Partners?
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