PARD3 and ACE2

Data Source:
BioGRID (pull down)

		PARD3	ACE2
Description		par-3 family cell polarity regulator	angiotensin converting enzyme 2
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Apical Plasma Membrane Cell Junction Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Apical Junction Complex Axonal Growth Cone	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Brush Border Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Identical Protein Binding	Virus Receptor Activity Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Identical Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Cycle Cell Adhesion Establishment Or Maintenance Of Cell Polarity Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Centrosome Localization Regulation Of Cellular Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity	Regulation Of Cytokine Production Angiotensin Maturation Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Tryptophan Transport Regulation Of Vasoconstriction Regulation Of Transmembrane Transporter Activity Regulation Of Cell Population Proliferation Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Regulation Of Inflammatory Response Positive Regulation Of Amino Acid Transport Positive Regulation Of Cardiac Muscle Contraction Blood Vessel Diameter Maintenance Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Positive Regulation Of L-proline Import Across Plasma Membrane Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions	Metabolism of Angiotensinogen to Angiotensins Attachment and Entry Potential therapeutics for SARS Attachment and Entry Attachment and Entry
Drugs			Chloroquine Hydroxychloroquine SPP1148 N-(2-Aminoethyl)-1-aziridineethanamine
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 28552196) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Parkinson's disease progression (composite) ( 33111402) Schizophrenia ( 21682944)
Interacting Genes		33 interacting genes: ACE2 AP1B1 CDC42 DYNLL1 F11R HNF1B INSC LIMK2 MAP3K8 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 TTN YWHAB YWHAG YWHAH YWHAZ	25 interacting genes: AGT CALM1 CDSN DEFA5 DLEU2 GHRL MAST1 MAST2 NTS PARD3 PDZK1 PTPN3 SCRIB SHANK1 SHANK2 SHANK3 SHROOM2 SLC6A19 SLC9A3R1 SLC9A3R2 SNX17 SNX27 TAMALIN TMPRSS11A TMPRSS11D
Entrez ID		56288	59272
HPRD ID		05994	02274
Ensembl ID		ENSG00000148498	ENSG00000130234
Uniprot IDs		Q8TEW0	Q9BYF1
PDB IDs		2KOM	1R42 1R4L 1XJP 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL 6ACG 6ACJ 6ACK 6CS2 6LZG 6M0J 6M17 6M18 6M1D 6VW1 7A91 7A92 7A94 7A95 7A96 7A97 7A98 7BH9 7CT5 7DF4 7DMU 7JVO 7KJ2 7KJ3 7KJ4 7KMB 7KMS 7KMZ 7KNB 7KNE 7KNH 7KNI 7L0N 7L7F
Enriched GO Terms of Interacting Partners?
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