RNF20 and PAF1

Number of citations of the paper that reports this interaction (PubMedID 24837678)
40

Data Source:
BioGRID (biochemical, biochemical, pull down)

		RNF20	PAF1
Description		ring finger protein 20	PAF1 homolog, Paf1/RNA polymerase II complex component
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus HULC Complex	Nucleoplasm Cytoplasm Membrane Cdc73/Paf1 Complex Cell Junction Transcriptionally Active Chromatin
	Molecular Function	P53 Binding Chromatin Binding Transcription Coactivator Activity MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Metal Ion Binding	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding
	Biological Process	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Histone Monoubiquitination Negative Regulation Of Cell Migration Positive Regulation Of Histone Methylation Histone H2B Ubiquitination Positive Regulation Of Transcription, DNA-templated Negative Regulation Of MRNA Polyadenylation Positive Regulation Of Histone H2B Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Nucleosome Positioning Stem Cell Population Maintenance Positive Regulation Of Histone Methylation Positive Regulation Of MRNA 3'-end Processing Histone H2B Ubiquitination Protein Localization To Nucleus Negative Regulation Of Myeloid Cell Differentiation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition
Pathways		E3 ubiquitin ligases ubiquitinate target proteins RHOBTB1 GTPase cycle	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS
Interacting Genes		36 interacting genes: AMOTL2 ATM BAG4 C1orf109 CDC73 EEF1D FBXO7 FGFR4 H2AC18 H2AC20 H2BC21 H2BC3 H3C14 H4C14 HSF1 HTT ITSN2 KIF11 MSL1 NCBP1 PA2G4 PAF1 PRPF8 RB1CC1 RNF40 SUMO2 TACC3 TRIM14 UBE2A UBE2B UBE2D2 UBE2E1 UBE2L3 USHBP1 XRCC3 ZDHHC17	18 interacting genes: ENO1 ERCC6 EXOSC5 FXR2 H1-2 H3C1 HSPB1 KAT8 KMT2A MLLT1 MSL1 MSL2 MSL3 RERE RNF20 SUMO2 TCEA1 TULP3
Entrez ID		56254	54623
HPRD ID		07410	10140
Ensembl ID		ENSG00000155827	ENSG00000006712
Uniprot IDs		Q5VTR2	A0A024R0H6 Q8N7H5
PDB IDs		5TRB	4M6T 5ZYQ 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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