PAF1 and ENO1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
13

Data Source:
BioGRID (two hybrid)

		PAF1	ENO1
Description		PAF1 homolog, Paf1/RNA polymerase II complex component	enolase 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Membrane Cdc73/Paf1 Complex Cell Junction Transcriptionally Active Chromatin	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane M Band Extracellular Exosome Cell Cortex Region
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding	Magnesium Ion Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Binding Phosphopyruvate Hydratase Activity Protein Binding Protein Homodimerization Activity Cadherin Binding GTPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Nucleosome Positioning Stem Cell Population Maintenance Positive Regulation Of Histone Methylation Positive Regulation Of MRNA 3'-end Processing Histone H2B Ubiquitination Protein Localization To Nucleus Negative Regulation Of Myeloid Cell Differentiation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition	Negative Regulation Of Transcription By RNA Polymerase II Glycolytic Process Response To Virus Positive Regulation Of Plasminogen Activation Negative Regulation Of Cell Growth Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Muscle Contraction Canonical Glycolysis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Biosynthetic Process
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Glycolysis Gluconeogenesis Manipulation of host energy metabolism
Drugs			Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Asthma ( 30929738) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Feeling tense ( 29500382) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		18 interacting genes: ENO1 ERCC6 EXOSC5 FXR2 H1-2 H3C1 HSPB1 KAT8 KMT2A MLLT1 MSL1 MSL2 MSL3 RERE RNF20 SUMO2 TCEA1 TULP3	65 interacting genes: AGTPBP1 ALDOA AMBP ANK3 ARID1B BCL6 BHLHE40 BRCA1 CBX5 CHEK2 CLK1 COL14A1 CYSLTR2 DES DUX4 FANCA FHL1 FLNC FXR1 FYN GLIS3 GRB2 HDAC1 HEMGN HEY2 HK2 HSP90AB1 HSPA8 HSPB2 ITGB1 IVNS1ABP KDM2A LIG4 LINC01554 LONRF3 MCPH1 MED13 MYOC NCOR1 OGT P4HB PAF1 PCNA PLG PPP2R5E RXFP3 SERPING1 SET SGCG SNAPC3 SRC SUMO2 SUMO4 TCAP TEAD1 TERT TNFRSF14 TRAPPC2 TTN TUBA1A UBE3A UPF2 YWHAQ YWHAZ ZBTB44
Entrez ID		54623	2023
HPRD ID		10140	01400
Ensembl ID		ENSG00000006712	ENSG00000074800
Uniprot IDs		A0A024R0H6 Q8N7H5	A0A024R4F1 P06733
PDB IDs		4M6T 5ZYQ 6GMH 6TED	2PSN 3B97 5JLZ 5LAX 5NI9 5NIG 5OCK
Enriched GO Terms of Interacting Partners?
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