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MAPK1 and MDFI
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
MAPK1
MDFI
Description
mitogen-activated protein kinase 1
MyoD family inhibitor
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Endoplasmic Reticulum Lumen
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Postsynaptic Density
Axon
Pseudopodium
Dendrite Cytoplasm
Protein-containing Complex
Azurophil Granule Lumen
Perikaryon
Mitotic Spindle
Ficolin-1-rich Granule Lumen
Nucleus
Cytoplasm
Molecular Function
Phosphotyrosine Residue Binding
Double-stranded DNA Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Identical Protein Binding
Protein Serine Kinase Activity
Protein Binding
Transcription Factor Binding
Identical Protein Binding
Transcription Regulator Inhibitor Activity
Biological Process
Protein Phosphorylation
Apoptotic Process
Chemotaxis
Cellular Response To DNA Damage Stimulus
Cell Cycle
Signal Transduction
Cell Surface Receptor Signaling Pathway
Chemical Synaptic Transmission
Aging
Learning Or Memory
Response To Toxic Substance
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Peptidyl-threonine Phosphorylation
Diadenosine Tetraphosphate Biosynthetic Process
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Sensory Perception Of Pain
Cytosine Metabolic Process
Regulation Of Ossification
Regulation Of Cellular PH
Thyroid Gland Development
Regulation Of Protein Stability
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Stress-activated MAPK Cascade
Mammary Gland Epithelial Cell Proliferation
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Response To Nicotine
Intracellular Signal Transduction
ERBB Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Outer Ear Morphogenesis
Response To Exogenous DsRNA
Response To Estrogen
Negative Regulation Of Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription, DNA-templated
Decidualization
Thymus Development
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Positive Regulation Of Telomerase Activity
Bergmann Glial Cell Differentiation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Long-term Synaptic Potentiation
Face Development
Lung Morphogenesis
Trachea Formation
Labyrinthine Layer Blood Vessel Development
Cardiac Neural Crest Cell Development Involved In Heart Development
ERK1 And ERK2 Cascade
Response To Epidermal Growth Factor
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Macrophage Proliferation
Cellular Response To Dopamine
Positive Regulation Of Telomere Capping
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Transcription By RNA Polymerase II
Dorsal/ventral Axis Specification
Negative Regulation Of Wnt Signaling Pathway
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of DNA Binding
Embryonic Skeletal System Morphogenesis
Trophoblast Giant Cell Differentiation
Pathways
phospho-PLA2 pathway
RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Spry regulation of FGF signaling
Golgi Cisternae Pericentriolar Stack Reorganization
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Recycling pathway of L1
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-stimulated signaling through PRKCZ
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by MAPK mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
Drugs
Acetylsalicylic acid
Minocycline
Isoprenaline
Arsenic trioxide
Olomoucine
Phosphonothreonine
Purvalanol
SB220025
Seliciclib
Perifosine
N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
(S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
(3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE
5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE
(1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione
[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine
Turpentine
Ulixertinib
Diseases
GWAS
Bipolar disorder (
31043756
)
Body size at age 10 (
32376654
)
Inflammatory bowel disease (
23128233
)
Multiple sclerosis (
31604244
24076602
21833088
)
Serum interleukin-6 concentration in active individuals (
32928877
)
Superior parietal cortex volume (
31530798
)
Grapefruit juice consumption (
31046077
)
Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) (
31557306
)
Interacting Genes
251 interacting genes:
AR
ARRB1
ARRB2
ATF2
ATP1A1
BANP
BCL2
BCL3
BCL6
BRAF
C1QBP
CACYBP
CAD
CALCOCO1
CAPN2
CASP8
CASP9
CAV1
CD19
CDC25C
CDX2
CEBPB
CEP55
CHN1
CITED2
CMTM3
COPS6
CREBBP
CRP
CSNK2A1
CTNND1
CTSD
CUEDC2
DAPK1
DUSP1
DUSP16
DUSP2
DUSP3
DUSP4
DUSP5
DUSP6
DUSP7
DUSP9
DYRK1B
EGFR
EGLN3
EIF4EBP1
ELK1
ELK4
ENAH
EP300
EPOR
ERF
ESR1
ESR2
ETS1
FCGR2B
FHL3
FOS
FOXO3
FRS2
FRS3
GAB1
GAB2
GABRR1
GAPDH
GATA1
GATA2
GATA4
GJA1
GMFB
GNPTAB
GORASP2
GRB10
GRB2
GSK3B
HDAC4
HDAC6
HIF1A
HNF4A
HOMEZ
HSF1
HSF4
HSP90AA1
ID2
IER3
IFI35
IFNAR1
ILF3
IQGAP1
IRS1
ITGB6
JUN
JUND
KARS1
KDR
KHDRBS1
KLF11
KRT8
KSR1
KSR2
LAMTOR3
LCK
LIFR
LIPE
LRPAP1
LRRC4
LZTS2
MAFA
MAP2K1
MAP2K2
MAP2K4
MAP2K6
MAP2K7
MAP3K1
MAP3K10
MAPK14
MAPK8
MAPKAPK5
MAPT
MBP
MCL1
MDFI
METAP2
METTL3
MITF
MKNK1
MKNK2
MSX2
MTIF3
MTPN
MYB
MYC
NCOA1
NCOA3
NDE1
NEFH
NEK2
NGFR
NKX2-1
NOXA1
NR3C1
NR4A1
NR4A2
NR5A1
NRL
NTRK3
NUP153
PAK1
PAK2
PAX5
PDE4D
PEA15
PEBP1
PKM
PLA2G4A
PLAGL2
PLAT
PLCB1
PLK3
POLR2G
PPARA
PPARG
PPP1CA
PPP1R18
PPP1R9B
PPP2CA
PPP2R5B
PPP2R5C
PRDX6
PRKCD
PRKCE
PRKCZ
PRPSAP1
PSMA1
PTPDC1
PTPN1
PTPN5
PTPN7
PTPRC
PTPRE
PTPRH
PTPRR
PXN
RAF1
RB1
REST
RET
RGS19
RNF216
RNF8
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RUNX1
RXRA
SCNN1G
SH2D3C
SHANK3
SHC1
SLC9A1
SMAD1
SMAD2
SMAD3
SMAD4
SNCA
SNCG
SORBS3
SOS1
SOX10
SP1
SREBF1
SREBF2
STAT3
STAT5A
STAT5B
STXBP1
STYX
SUPT20H
TCF3
TFCP2
TGIF1
TH
TIAL1
TLE5
TNFRSF1A
TNFRSF25
TNFSF11
TNIP1
TNIP2
TNKS2
TOB1
TOP2A
TP53
TPR
TSC2
TTN
TXNIP
UBE3A
UBR5
UBTF
VAV1
VDR
YBX1
YBX3
ZBTB42
ZC3HC1
ZFP36
406 interacting genes:
AANAT
AASDHPPT
ABCF3
ABHD11
ABHD17A
ADAMTSL3
ADRA2C
AEBP2
AGXT
AKAP17A
AP5Z1
APLN
AQP1
AQP5
ARHGAP32
ARID5A
ARMC7
ATG12
ATN1
ATP5F1D
ATP6V0C
ATXN7L2
AVPI1
AXIN1
B3GNT9
BAALC
BAG3
BAHD1
BANP
BBS2
BCAM
BCL6
BCL6B
BEX1
BEX2
BEX3
C10orf62
C1orf216
C22orf39
C4orf45
C8orf33
C8orf48
CATSPER1
CBFA2T2
CBLL2
CBX2
CBX8
CC2D1B
CCDC116
CCDC120
CCDC185
CCDC187
CCDC198
CCDC33
CCER1
CCNL2
CDC20B
CDC37
CDC42EP1
CDCA7L
CDKL3
CEP57L1
CFAP206
CHIC2
CHP2
CHRNG
CLPB
CNNM3
CRACR2A
CREB5
CRH
CRX
CRY1
CSNK1G2-AS1
CSNK1G3
CTRC
CXCL16
CYBA
DAAM2
DBF4B
DCAF6
DCAF8
DCANP1
DDX19A
DHRS1
DKK1
DMRT3
DNAJB13
DNMT3A
DNPEP
DOCK2
DOK3
DUSP6
DYNLT4
EBI3
EFEMP2
EIF4A2
EIF4E2
ELOA
ENKD1
ETNK2
EWSR1
FAAP100
FADS6
FAM120AOS
FAM124B
FAM161A
FAM161B
FAM214B
FAM27E3
FAM90A1
FARS2
FASTK
FBXL18
FBXO34
FBXW5
FES
FEZF1
FNDC11
FOXD4
FOXD4L1
FOXD4L3
FOXD4L6
FZD9
GABRD
GATA1
GATA2
GDF15
GLIDR
GLRX3
GNAI2
GNE
GNG5
GPANK1
GPATCH2L
GPRIN2
GREM1
GTF3C5
HAPLN2
HASPIN
HEYL
HHEX
HHLA3
HNRNPLL
HOXA1
HOXB9
HPCAL1
HTR1B
HYPK
IFRD2
ILF3
INTS11
IQUB
ITGB4
JOSD1
KANSL1
KAT5
KCTD7
KIAA0040
KIAA0408
KIF1A
KLHL38
KPNA2
KRAS
KRT77
LAMB3
LASP1
LCE1A
LCE1B
LCE1D
LCE1F
LCE2B
LCE3A
LCE3C
LCE3D
LCE3E
LCE4A
LIMS2
LIN7A
LINC00636
LINC01588
LMO3
LRCH4
LRRN4
MACIR
MAGEC3
MAGED1
MAGEF1
MAPK1
MAPKBP1
MBD1
MBD3L2
MCM5
MEOX2
METTL17
MFSD3
MGAT5B
MRPL20-AS1
MVP
MXI1
MYF5
MYOD1
MYOG
MYPOP
NAB2
NDUFA7
NECTIN2
NEU4
NIBAN3
NKD1
NOL4L-DT
NPDC1
NPEPL1
NR1H2
NR1H3
NSD1
NTAQ1
NUBP2
NUFIP2
ODAD4
ODAPH
ODF1
ODF3B
OLIG3
OTX1
PARP11
PATZ1
PBXIP1
PCSK5
PDGFA
PDGFB
PDIA5
PDS5A
PELI2
PGLS
PHF1
PHLDA1
PIBF1
PID1
PIDD1
PIH1D2
PIN1
PKD2
PLEKHG4
POLL
POM121L8P
PRKAB2
PRPF18
PRPF31
PRR34
PTK7
PTPMT1
RABL6
RAC1
RASD1
REG3A
REX1BD
RFX2
RHOXF2
RIN1
RIPPLY1
RNF111
RNF6
RTP5
SAPCD2
SCAMP4
SCNM1
SELENOM
SEMA3B
SERF2
SFI1
SHFL
SHMT1
SIX1
SLC13A5
SLC15A3
SLC25A10
SLC35A2
SLC9A1
SMYD1
SNX18
SOCS7
SPATA24
SPATA3
SPATA8
SPG7
SPON1
SPRED2
SPRY1
SPRY2
SUOX
TACO1
TAP1
TASOR2
TBC1D3B
TBC1D3G
TCEANC
TCF3
TEAD4
TEDC2
TGIF1
TH
THAP7
THEG
TIE1
TINAGL1
TLE5
TMEM241
TMIE
TNNI1
TNP2
TOR1A
TRAF3IP2
TRIB3
TRPC1
TRPV6
TSC2
TSFM
TSGA10IP
TSPAN4
TSPYL1
TSPYL6
TTC23
TTLL10
TUSC2
TXN2
TYMSOS
TYRO3
USP20
USP6
VASN
VGLL3
VHL
VPS72
VSTM4
WDFY3
WNT11
YPEL3
YY1
ZBBX
ZBTB24
ZBTB25
ZBTB42
ZBTB9
ZC3HAV1
ZDHHC1
ZFYVE26
ZIM2
ZNF101
ZNF12
ZNF124
ZNF136
ZNF138
ZNF155
ZNF205
ZNF221
ZNF223
ZNF23
ZNF230
ZNF264
ZNF266
ZNF330
ZNF408
ZNF414
ZNF417
ZNF426
ZNF433
ZNF438
ZNF439
ZNF440
ZNF441
ZNF446
ZNF461
ZNF479
ZNF490
ZNF491
ZNF497
ZNF512B
ZNF524
ZNF559
ZNF564
ZNF572
ZNF575
ZNF578
ZNF580
ZNF581
ZNF587
ZNF607
ZNF613
ZNF646
ZNF648
ZNF662
ZNF669
ZNF670
ZNF679
ZNF688
ZNF696
ZNF707
ZNF764
ZNF784
ZNF785
ZNF786
ZNF79
ZNF837
ZNF844
ZNHIT1
Entrez ID
5594
4188
HPRD ID
01496
07280
Ensembl ID
ENSG00000100030
ENSG00000112559
Uniprot IDs
P28482
Q1HBJ4
Q499G7
A0A024RCY2
B1AKB6
Q99750
PDB IDs
1PME
1TVO
1WZY
2OJG
2OJI
2OJJ
2Y9Q
3D42
3D44
3I5Z
3I60
3SA0
3TEI
3W55
4FMQ
4FUX
4FUY
4FV0
4FV1
4FV2
4FV3
4FV4
4FV5
4FV6
4FV7
4FV8
4FV9
4G6N
4G6O
4H3P
4H3Q
4IZ5
4IZ7
4IZA
4N0S
4NIF
4O6E
4QP1
4QP2
4QP3
4QP4
4QP6
4QP7
4QP8
4QP9
4QPA
4QTA
4QTE
4XJ0
4ZXT
4ZZM
4ZZN
4ZZO
5AX3
5BUE
5BUI
5BUJ
5BVD
5BVE
5BVF
5K4I
5LCJ
5LCK
5NGU
5NHF
5NHH
5NHJ
5NHL
5NHO
5NHP
5NHV
5V60
5V61
5V62
5WP1
6D5Y
6DMG
6G54
6G8X
6G91
6G92
6G93
6G97
6G9A
6G9D
6G9H
6G9J
6G9K
6G9M
6G9N
6GDM
6GDQ
6GE0
6GJB
6GJD
6NBS
6OPG
6OPH
6OPI
6Q7K
6Q7S
6Q7T
6QA1
6QA3
6QA4
6QAG
6QAH
6QAL
6QAQ
6QAW
6RQ4
6SLG
Enriched GO Terms of Interacting Partners
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