MDFI and TH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MDFI	TH
Description		MyoD family inhibitor	tyrosine hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Mitochondrion Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Axon Dendrite Cytoplasmic Vesicle Melanosome Membrane Neuron Projection Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Transcription Factor Binding Identical Protein Binding Transcription Regulator Inhibitor Activity	Tyrosine 3-monooxygenase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Amino Acid Binding Oxygen Binding Enzyme Binding Protein Domain Specific Binding Tetrahydrobiopterin Binding Dopamine Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Dorsal/ventral Axis Specification Negative Regulation Of Wnt Signaling Pathway Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA Binding Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation	Response To Hypoxia Synaptic Transmission, Dopaminergic Response To Amphetamine Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Fatty Acid Metabolic Process Sphingolipid Metabolic Process Heart Development Visual Perception Sensory Perception Of Sound Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Response To Water Deprivation Response To Light Stimulus Response To Herbicide Response To Salt Stress Anatomical Structure Morphogenesis Animal Organ Morphogenesis Response To Zinc Ion Multicellular Organism Aging Response To Activity Aminergic Neurotransmitter Loading Into Synaptic Vesicle Glycoside Metabolic Process Phthalate Metabolic Process Cerebral Cortex Development Response To Nutrient Levels Response To Estradiol Response To Lipopolysaccharide Isoquinoline Alkaloid Metabolic Process Social Behavior Response To Isolation Stress Response To Immobilization Stress Neurotransmitter Biosynthetic Process Terpene Metabolic Process Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Eye Photoreceptor Cell Development Circadian Sleep/wake Cycle Eating Behavior Response To Peptide Hormone Pigmentation Response To Ethanol Response To Ether Response To Pyrethroid Embryonic Camera-type Eye Morphogenesis Response To Corticosterone Response To Electrical Stimulus Phytoalexin Metabolic Process Cellular Response To Manganese Ion Cellular Response To Alkaloid Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Hyaloid Vascular Plexus Regression
Pathways			Catecholamine biosynthesis
Drugs			Phenylalanine Tyrosine Sapropterin Metyrosine 3-Tyrosine L-erythro-7,8-dihydrobiopterin
Diseases
GWAS		Grapefruit juice consumption ( 31046077) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)	Celiac disease ( 23936387) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Prostate cancer ( 19767753) Prostate cancer (early onset) ( 24740154) Prostate cancer (SNP x SNP interaction) ( 22219177) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 31324766 25102180)
Interacting Genes		406 interacting genes: AANAT AASDHPPT ABCF3 ABHD11 ABHD17A ADAMTSL3 ADRA2C AEBP2 AGXT AKAP17A AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ARMC7 ATG12 ATN1 ATP5F1D ATP6V0C ATXN7L2 AVPI1 AXIN1 B3GNT9 BAALC BAG3 BAHD1 BANP BBS2 BCAM BCL6 BCL6B BEX1 BEX2 BEX3 C10orf62 C1orf216 C22orf39 C4orf45 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBLL2 CBX2 CBX8 CC2D1B CCDC116 CCDC120 CCDC185 CCDC187 CCDC198 CCDC33 CCER1 CCNL2 CDC20B CDC37 CDC42EP1 CDCA7L CDKL3 CEP57L1 CFAP206 CHIC2 CHP2 CHRNG CLPB CNNM3 CRACR2A CREB5 CRH CRX CRY1 CSNK1G2-AS1 CSNK1G3 CTRC CXCL16 CYBA DAAM2 DBF4B DCAF6 DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNAJB13 DNMT3A DNPEP DOCK2 DOK3 DUSP6 DYNLT4 EBI3 EFEMP2 EIF4A2 EIF4E2 ELOA ENKD1 ETNK2 EWSR1 FAAP100 FADS6 FAM120AOS FAM124B FAM161A FAM161B FAM214B FAM27E3 FAM90A1 FARS2 FASTK FBXL18 FBXO34 FBXW5 FES FEZF1 FNDC11 FOXD4 FOXD4L1 FOXD4L3 FOXD4L6 FZD9 GABRD GATA1 GATA2 GDF15 GLIDR GLRX3 GNAI2 GNE GNG5 GPANK1 GPATCH2L GPRIN2 GREM1 GTF3C5 HAPLN2 HASPIN HEYL HHEX HHLA3 HNRNPLL HOXA1 HOXB9 HPCAL1 HTR1B HYPK IFRD2 ILF3 INTS11 IQUB ITGB4 JOSD1 KANSL1 KAT5 KCTD7 KIAA0040 KIAA0408 KIF1A KLHL38 KPNA2 KRAS KRT77 LAMB3 LASP1 LCE1A LCE1B LCE1D LCE1F LCE2B LCE3A LCE3C LCE3D LCE3E LCE4A LIMS2 LIN7A LINC00636 LINC01588 LMO3 LRCH4 LRRN4 MACIR MAGEC3 MAGED1 MAGEF1 MAPK1 MAPKBP1 MBD1 MBD3L2 MCM5 MEOX2 METTL17 MFSD3 MGAT5B MRPL20-AS1 MVP MXI1 MYF5 MYOD1 MYOG MYPOP NAB2 NDUFA7 NECTIN2 NEU4 NIBAN3 NKD1 NOL4L-DT NPDC1 NPEPL1 NR1H2 NR1H3 NSD1 NTAQ1 NUBP2 NUFIP2 ODAD4 ODAPH ODF1 ODF3B OLIG3 OTX1 PARP11 PATZ1 PBXIP1 PCSK5 PDGFA PDGFB PDIA5 PDS5A PELI2 PGLS PHF1 PHLDA1 PIBF1 PID1 PIDD1 PIH1D2 PIN1 PKD2 PLEKHG4 POLL POM121L8P PRKAB2 PRPF18 PRPF31 PRR34 PTK7 PTPMT1 RABL6 RAC1 RASD1 REG3A REX1BD RFX2 RHOXF2 RIN1 RIPPLY1 RNF111 RNF6 RTP5 SAPCD2 SCAMP4 SCNM1 SELENOM SEMA3B SERF2 SFI1 SHFL SHMT1 SIX1 SLC13A5 SLC15A3 SLC25A10 SLC35A2 SLC9A1 SMYD1 SNX18 SOCS7 SPATA24 SPATA3 SPATA8 SPG7 SPON1 SPRED2 SPRY1 SPRY2 SUOX TACO1 TAP1 TASOR2 TBC1D3B TBC1D3G TCEANC TCF3 TEAD4 TEDC2 TGIF1 TH THAP7 THEG TIE1 TINAGL1 TLE5 TMEM241 TMIE TNNI1 TNP2 TOR1A TRAF3IP2 TRIB3 TRPC1 TRPV6 TSC2 TSFM TSGA10IP TSPAN4 TSPYL1 TSPYL6 TTC23 TTLL10 TUSC2 TXN2 TYMSOS TYRO3 USP20 USP6 VASN VGLL3 VHL VPS72 VSTM4 WDFY3 WNT11 YPEL3 YY1 ZBBX ZBTB24 ZBTB25 ZBTB42 ZBTB9 ZC3HAV1 ZDHHC1 ZFYVE26 ZIM2 ZNF101 ZNF12 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF221 ZNF223 ZNF23 ZNF230 ZNF264 ZNF266 ZNF330 ZNF408 ZNF414 ZNF417 ZNF426 ZNF433 ZNF438 ZNF439 ZNF440 ZNF441 ZNF446 ZNF461 ZNF479 ZNF490 ZNF491 ZNF497 ZNF512B ZNF524 ZNF559 ZNF564 ZNF572 ZNF575 ZNF578 ZNF580 ZNF581 ZNF587 ZNF607 ZNF613 ZNF646 ZNF648 ZNF662 ZNF669 ZNF670 ZNF679 ZNF688 ZNF696 ZNF707 ZNF764 ZNF784 ZNF785 ZNF786 ZNF79 ZNF837 ZNF844 ZNHIT1	32 interacting genes: CAMK2G CDK11B CRABP1 CSNK2A1 DAAM2 GAD1 HLA-G HNRNPK MAPK1 MAPK3 MAPKAPK2 MDFI NFIC NPAS1 PHLDA2 PIAS2 PRKACA PUF60 RBMY1A1 RNH1 RPS6KA5 SHC1 SNCA STIM1 TNNI2 TRIM21 TSPYL4 TYSND1 UMAD1 YWHAB YWHAZ ZNF569
Entrez ID		4188	7054
HPRD ID		07280	01865
Ensembl ID		ENSG00000112559	ENSG00000180176
Uniprot IDs		A0A024RCY2 B1AKB6 Q99750	P07101 P78428
PDB IDs			2XSN 4J6S
Enriched GO Terms of Interacting Partners?
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