KMT2E and NFE4

		KMT2E	NFE4
Description		lysine methyltransferase 2E (inactive)	nuclear factor, erythroid 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Nuclear Body Nuclear Speck Protein-containing Complex Transcriptionally Active Chromatin	Nucleus Protein-containing Complex
	Molecular Function	Protein Binding Histone-lysine N-methyltransferase Activity Enzyme Binding Methylated Histone Binding Metal Ion Binding	Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding Protein Homodimerization Activity DNA-binding Transcription Factor Binding
	Biological Process	Neutrophil Mediated Immunity DNA Methylation Chromatin Organization Cell Cycle Erythrocyte Differentiation Neutrophil Activation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Histone H3-K4 Trimethylation	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)
Interacting Genes		12 interacting genes: ALKBH4 ASH2L ATP13A1 CDK1 CYP2C18 FIS1 IFT22 LAMTOR5 MAPRE2 NFE4 TRAPPC14 ZCWPW1	5 interacting genes: HDAC1 KAT2B KMT2E MEPCE TFCP2
Entrez ID		55904	58160
HPRD ID		10528	19326
Ensembl ID		ENSG00000005483	ENSG00000230257
Uniprot IDs		Q8IZD2	Q86UQ8
PDB IDs		2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?
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