PRKCH and PARD6A

Number of citations of the paper that reports this interaction (PubMedID 17335965)
10

Data Source:
HPRD (in vivo)

		PRKCH	PARD6A
Description		protein kinase C eta	par-6 family cell polarity regulator alpha
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Ruffle Nucleus Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Apical Plasma Membrane Centriolar Satellite
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Enzyme Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Kinase C Binding Protein Binding Transcription Factor Binding GTP-dependent Protein Binding Small GTPase Binding
	Biological Process	Protein Phosphorylation Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Peptidyl-serine Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Bicellular Tight Junction Assembly	Negative Regulation Of Protein Phosphorylation Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Viral Process Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Regulation Of Cellular Localization Positive Regulation Of Protein Localization To Centrosome
Pathways		Effects of PIP2 hydrolysis G alpha (z) signalling events	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle RHOV GTPase cycle
Drugs
Diseases
GWAS		Asthma ( 32296059) Height ( 28552196) Obesity (early onset extreme) ( 23563609) Reading and spelling ( 23738518) Rheumatoid arthritis ( 30423114 22446963 24390342) Word reading ( 23738518) Yeast infection ( 28928442)	Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		17 interacting genes: BANP BMP4 C14orf39 CDK2 FYN GSK3A ITGB2 NUMB PARD6A PPP1R14A PRKD1 PTPN11 SIX6 SRC ZBTB8OS ZFP36L1 ZFYVE1	27 interacting genes: APP ATP5MG CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ
Entrez ID		5583	50855
HPRD ID		05669	06316
Ensembl ID		ENSG00000027075	ENSG00000102981
Uniprot IDs		P24723	Q9NPB6
PDB IDs		2FK9 3TXO	1WMH
Enriched GO Terms of Interacting Partners?
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