MINDY1 and OTUD7B

		MINDY1	OTUD7B
Description		MINDY lysine 48 deubiquitinase 1	OTU deubiquitinase 7B
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Nuclear Body Cell Periphery	Nucleus Cytoplasm Cytosol
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Carboxypeptidase Activity K48-linked Polyubiquitin Modification-dependent Protein Binding Lys48-specific Deubiquitinase Activity	DNA Binding Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Lys48-specific Deubiquitinase Activity
	Biological Process	Biological_process Protein K48-linked Deubiquitination	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Adaptive Immune Response Mucosal Immune Response Protein Deubiquitination Negative Regulation Of Interleukin-8 Production Protein K11-linked Deubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Localization To Nucleus
Pathways			TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ovarian tumor domain proteases
Drugs
Diseases
GWAS			Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Heel bone mineral density ( 30598549) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		5 interacting genes: DAZAP2 GMCL1 LSM8 OTUD7B UBC	23 interacting genes: AURKA C1orf54 CCNB1 CDC20 CDC42SE1 CDIP1 DAZAP2 EPM2AIP1 FZR1 HSFY1 HSFY2 MINDY1 OTULIN PIK3C3 PPP1R32 PSMB1 SOX2 SPART TNFAIP8L2 TRAF6 UBC UBE2S ZDHHC17
Entrez ID		55793	56957
HPRD ID		07746	10313
Ensembl ID		ENSG00000143409	ENSG00000264522
Uniprot IDs		D3DV11 Q8N5J2	Q6GQQ9
PDB IDs		5JKN 5JQS 5MN9 6TUV 6TXB	5LRU 5LRV 5LRW
Enriched GO Terms of Interacting Partners?
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