OTUD7B and PIK3C3

Number of citations of the paper that reports this interaction (PubMedID 32453962)
1

Data Source:
BioGRID (enzymatic study)

		OTUD7B	PIK3C3
Description		OTU deubiquitinase 7B	phosphatidylinositol 3-kinase catalytic subunit type 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Phagophore Assembly Site Cytoplasm Endosome Late Endosome Peroxisome Cytosol Axoneme Membrane Midbody Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Autolysosome
	Molecular Function	DNA Binding Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Lys48-specific Deubiquitinase Activity	Protein Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Adaptive Immune Response Mucosal Immune Response Protein Deubiquitination Negative Regulation Of Interleukin-8 Production Protein K11-linked Deubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Localization To Nucleus	Autophagosome Assembly Protein Phosphorylation Protein Lipidation Endocytosis Autophagy Endosome Organization Cell Cycle Macroautophagy Protein Processing Autophagy Of Peroxisome Regulation Of Cytokinesis Protein Localization To Phagophore Assembly Site Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Response To Leucine Early Endosome To Late Endosome Transport Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Regulation Of Protein Secretion Cell Division
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ovarian tumor domain proteases	PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs			N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Heel bone mineral density ( 30598549) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172)	Adult body size ( 32376654) Blood trace element (Zn levels) ( 23720494) Body size at age 10 ( 32376654) Frailty index ( 34431594) General risk tolerance (MTAG) ( 30643258) Major depressive disorder (MTAG) ( 33479212) Obese vs. thin ( 30677029) Obesity-related traits ( 23251661) Periodontitis (PAL4Q3) ( 24024966) Walking pace ( 33128006)
Interacting Genes		23 interacting genes: AURKA C1orf54 CCNB1 CDC20 CDC42SE1 CDIP1 DAZAP2 EPM2AIP1 FZR1 HSFY1 HSFY2 MINDY1 OTULIN PIK3C3 PPP1R32 PSMB1 SOX2 SPART TNFAIP8L2 TRAF6 UBC UBE2S ZDHHC17	10 interacting genes: CALM1 CASP8 FBXL20 OTUD7B PDPK1 PIK3R4 PITPNA STYK1 YWHAG YWHAQ
Entrez ID		56957	5289
HPRD ID		10313	04009
Ensembl ID		ENSG00000264522	ENSG00000078142
Uniprot IDs		Q6GQQ9	A8MYT4 B4DPV9 Q8NEB9
PDB IDs		5LRU 5LRV 5LRW	3IHY 3LS8 4OYS 4PH4 4UWF 4UWG 4UWH 4UWK 4UWL 5ANL 5ENN 6I3U 7BL1
Enriched GO Terms of Interacting Partners?
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