PRKAR2B and AKAP7

Number of citations of the paper that reports this interaction (PubMedID 26186194)
524

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid)

		PRKAR2B	AKAP7
Description		protein kinase cAMP-dependent type II regulatory subunit beta	A-kinase anchoring protein 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Neuronal Cell Body Dendritic Spine Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Glutamatergic Synapse	Nucleus Cytosol Protein-containing Complex Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Nucleotide Binding Protein Binding Protein Kinase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
	Biological Process	Fatty Acid Metabolic Process Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Response To Clozapine Negative Regulation Of CAMP-dependent Protein Kinase Activity	Biological_process Regulation Of Protein Kinase A Signaling Modulation Of Chemical Synaptic Transmission
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs		Cyclic adenosine monophosphate
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)	Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hip circumference adjusted for BMI ( 34021172) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		26 interacting genes: ABCB4 AKAP1 AKAP10 AKAP11 AKAP14 AKAP4 AKAP5 AKAP7 AKAP9 C2orf88 CBR1 CFAP91 ECM1 GNAI3 KIF5B LAMB1 LASP1 LRCH4 MT1H NBEA OGT PAK1IP1 RAP2B RPL30 TAF12 TFR2	9 interacting genes: C8orf34 CEP76 PRKAR1A PRKAR1B PRKAR2A PRKAR2B ROPN1 ROPN1L SPA17
Entrez ID		5577	9465
HPRD ID		01486	16065
Ensembl ID		ENSG00000005249	ENSG00000118507
Uniprot IDs		A0A024R712 B3KY43 P31323	O43687 Q2TAJ5 Q6P4D3 Q9P0M2
PDB IDs			4ZP3 5JJ2
Enriched GO Terms of Interacting Partners?
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