PRKAR2B and AKAP1

Number of citations of the paper that reports this interaction (PubMedID 10764601)
68

Data Source:
HPRD (in vitro, in vivo)

		PRKAR2B	AKAP1
Description		protein kinase cAMP-dependent type II regulatory subunit beta	A-kinase anchoring protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Neuronal Cell Body Dendritic Spine Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Glutamatergic Synapse	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Membrane
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	RNA Binding Protein Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Fatty Acid Metabolic Process Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Response To Clozapine Negative Regulation Of CAMP-dependent Protein Kinase Activity	Apoptotic Process Antiviral Innate Immune Response
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	Mitochondrial calcium ion transport Factors involved in megakaryocyte development and platelet production
Drugs		Cyclic adenosine monophosphate
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)	Blond vs. brown/black hair color ( 30531825) Crohn's disease ( 26192919) Freckles ( 29895819) Inflammatory bowel disease ( 26192919) Male-pattern baldness ( 27182965)
Interacting Genes		26 interacting genes: ABCB4 AKAP1 AKAP10 AKAP11 AKAP14 AKAP4 AKAP5 AKAP7 AKAP9 C2orf88 CBR1 CFAP91 ECM1 GNAI3 KIF5B LAMB1 LASP1 LRCH4 MT1H NBEA OGT PAK1IP1 RAP2B RPL30 TAF12 TFR2	12 interacting genes: AMY1A CAV1 CFAP91 DYSF MYCBP PPP1CA PRKACA PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTPN21
Entrez ID		5577	8165
HPRD ID		01486	03905
Ensembl ID		ENSG00000005249	ENSG00000121057
Uniprot IDs		A0A024R712 B3KY43 P31323	A0A140VK05 B4DN86 Q92667
PDB IDs
Enriched GO Terms of Interacting Partners?
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