PRKAR2A and AKAP7

Number of citations of the paper that reports this interaction (PubMedID 12672969)
67

Data Source:
HPRD (in vivo, in vitro)

		PRKAR2A	AKAP7
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	A-kinase anchoring protein 7
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Nucleus Cytosol Protein-containing Complex Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Nucleotide Binding Protein Binding Protein Kinase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
	Biological Process	Intracellular Signal Transduction Negative Regulation Of CAMP-dependent Protein Kinase Activity	Biological_process Regulation Of Protein Kinase A Signaling Modulation Of Chemical Synaptic Transmission
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs		GEM-231
Diseases
GWAS		Apolipoprotein A1 levels ( 33730874) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hip circumference adjusted for BMI ( 34021172) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		44 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CFTR EZR FOS GABARAPL2 HYAL1 LRIF1 MAP2 MSN MYCBPAP NBEA OGT P4HA2 PJA2 PPP1CB PRKX RAB32 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 XCR1	9 interacting genes: C8orf34 CEP76 PRKAR1A PRKAR1B PRKAR2A PRKAR2B ROPN1 ROPN1L SPA17
Entrez ID		5576	9465
HPRD ID		01484	16065
Ensembl ID		ENSG00000114302	ENSG00000118507
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A8KAH7 P13861	O43687 Q2TAJ5 Q6P4D3 Q9P0M2
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY	4ZP3 5JJ2
Enriched GO Terms of Interacting Partners?
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