PRKAR2A and XCR1

		PRKAR2A	XCR1
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	X-C motif chemokine receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Intracellular Signal Transduction Negative Regulation Of CAMP-dependent Protein Kinase Activity	Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	Chemokine receptors bind chemokines G alpha (q) signalling events
Drugs		GEM-231
Diseases
GWAS		Apolipoprotein A1 levels ( 33730874) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Aspartate aminotransferase levels ( 33547301) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		44 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CFTR EZR FOS GABARAPL2 HYAL1 LRIF1 MAP2 MSN MYCBPAP NBEA OGT P4HA2 PJA2 PPP1CB PRKX RAB32 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 XCR1	5 interacting genes: PLEKHF2 PRKAR2A TOPAZ1 XCL1 XCL2
Entrez ID		5576	2829
HPRD ID		01484	02774
Ensembl ID		ENSG00000114302	ENSG00000173578
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A8KAH7 P13861	P46094 Q502V0 Q689E2
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY
Enriched GO Terms of Interacting Partners?
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