PRKAG1 and PRKAB1

Number of citations of the paper that reports this interaction (PubMedID 10698692)
181

Data Source:
HPRD (two hybrid)

		PRKAG1	PRKAB1
Description		protein kinase AMP-activated non-catalytic subunit gamma 1	protein kinase AMP-activated non-catalytic subunit beta 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding	Protein Kinase Activity Protein Binding Protein Kinase Binding
	Biological Process	Regulation Of Glycolytic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Signal Transduction Spermatogenesis Positive Regulation Of Gene Expression Cellular Response To Glucose Starvation Positive Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Import Into Nucleus Regulation Of Protein Serine/threonine Kinase Activity	Protein Phosphorylation Fatty Acid Biosynthetic Process Signal Transduction Positive Regulation Of Gene Expression Nail Development Regulation Of Catalytic Activity Regulation Of Primary Metabolic Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs		Adenosine phosphate Acetylsalicylic acid Fostamatinib	Adenosine phosphate Adenosine phosphate Metformin Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Bipolar disorder ( 31043756) Body mass index ( 29273807) HDL cholesterol ( 30275531) Pulse pressure ( 27618447) Red cell distribution width ( 32888494) Systolic blood pressure ( 27618447 30578418)	Basophil count ( 32888494) Inflammatory bowel disease ( 26192919) Lymphocyte percentage of white cells ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte count ( 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Ulcerative colitis ( 26192919) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: ACACA AP1S3 C1orf94 CBS CRBN EIF3G KCNN4 KEAP1 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP4-12 KRTAP4-2 KRTAP9-2 KRTAP9-8 MEOX1 MEOX2 PAICS PAX6 PLEKHF2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 SHMT2 TEKT1 TNFAIP1 TUBA1C	12 interacting genes: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2
Entrez ID		5571	5564
HPRD ID		04118	04116
Ensembl ID		ENSG00000181929	ENSG00000111725
Uniprot IDs		A0A024R125 P54619	A0A024RBN1 Q9Y478
PDB IDs		2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J	4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6C9F 6C9G 6C9H 6C9J
Enriched GO Terms of Interacting Partners?
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