PRKAB1 and PRKAG2

Number of citations of the paper that reports this interaction (PubMedID 10698692)
181

Data Source:
HPRD (two hybrid)

		PRKAB1	PRKAG2
Description		protein kinase AMP-activated non-catalytic subunit beta 1	protein kinase AMP-activated non-catalytic subunit gamma 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Protein Kinase Activity Protein Binding Protein Kinase Binding	AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity Phosphorylase Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Kinase Activator Activity ADP Binding
	Biological Process	Protein Phosphorylation Fatty Acid Biosynthetic Process Signal Transduction Positive Regulation Of Gene Expression Nail Development Regulation Of Catalytic Activity Regulation Of Primary Metabolic Process Positive Regulation Of Cold-induced Thermogenesis	Glycogen Metabolic Process Regulation Of Glycolytic Process Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Fatty Acid Biosynthetic Process ATP Biosynthetic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Sterol Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Activation Of Protein Kinase Activity Intracellular Signal Transduction Cellular Response To Glucose Starvation Positive Regulation Of Protein Kinase Activity Regulation Of Fatty Acid Oxidation Regulation Of Glucose Import Regulation Of Catalytic Activity Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs		Adenosine phosphate Adenosine phosphate Metformin Acetylsalicylic acid Fostamatinib	Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Basophil count ( 32888494) Inflammatory bowel disease ( 26192919) Lymphocyte percentage of white cells ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte count ( 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Ulcerative colitis ( 26192919) White blood cell count ( 32888494)	Bipolar disorder (age of onset and psychotic symptoms) ( 21305692) Blood urea nitrogen levels ( 31152163) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate (creatinine, CKDi25) ( 33137338) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in diabetes ( 29703844) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glomerular filtration rate in type 2 diabetes ( 29703844) Gout ( 33832965) Gut microbiota (beta diversity) ( 27723756) Hematocrit ( 32888494 27863252 28017375 19862010) Hemoglobin ( 32888494 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) Intraocular pressure ( 29785010 31959993) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolite levels (small molecules and protein measures) ( 27005778) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494 28453575 27863252) Red blood cell traits ( 23222517) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 27618447 30578418) Urate levels ( 31578528 23263486) Urea levels ( 31015462 28270201) Urinary albumin excretion ( 32277301)
Interacting Genes		12 interacting genes: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2	6 interacting genes: CHPF2 DAPK1 MFHAS1 PRKAB1 PRKAB2 PRKAG1
Entrez ID		5564	51422
HPRD ID		04116	04119
Ensembl ID		ENSG00000111725	ENSG00000106617
Uniprot IDs		A0A024RBN1 Q9Y478	A0A090N8Q6 A0A384MDZ2 A0A494C068 A0A494C1K7 B7Z6X8 E9PGP6 Q9UGJ0
PDB IDs		4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6C9F 6C9G 6C9H 6C9J
Enriched GO Terms of Interacting Partners?
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