ZNF446 and FRMD8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ZNF446	FRMD8
Description		zinc finger protein 446	FERM domain containing 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Extracellular Space Nucleus	Nucleoplasm Cytosol Plasma Membrane Centriolar Satellite
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Uric acid clearance ( 28095793)	Acne (severe) ( 24927181) Alanine aminotransferase levels ( 33547301) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Serum uric acid levels ( 32514006 32271837) Urate levels ( 31578528)
Interacting Genes		60 interacting genes: ACTN2 ANKRD1 CCNK COPS2 CYSRT1 DGCR6 DGCR6L EHMT2 EVI5 FHL5 FRMD8 FRS3 GOLGA6L9 INCA1 KIFC3 KRT31 KRT34 KRT35 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP3-1 LNX1 LZTS2 MAGOHB MDFI NBPF19 NOTCH2NLA PGBD1 PIN1 REL SCAND1 SIVA1 SUFU TAX1BP1 TRIM27 UBE2I UBE3A ZKSCAN4 ZKSCAN7 ZNF165 ZNF18 ZNF232 ZNF24 ZNF263 ZNF396 ZNF397 ZNF483 ZNF496 ZSCAN12 ZSCAN16 ZSCAN18 ZSCAN21 ZSCAN22 ZSCAN23 ZSCAN29 ZSCAN30 ZSCAN32 ZSCAN9	9 interacting genes: APP FATE1 GRAMD2B IKBKG KCNH2 LIME1 PLEKHF2 ZNF446 ZNF474
Entrez ID		55663	83786
HPRD ID		07934	13326
Ensembl ID		ENSG00000083838	ENSG00000126391
Uniprot IDs		Q8NDK2 Q9NWS9 Q9UFF2	A8K6L3 Q9BZ67
PDB IDs
Enriched GO Terms of Interacting Partners?
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