OTUB1 and SLC7A11

Number of citations of the paper that reports this interaction (PubMedID 30709928)
50

Data Source:
BioGRID (pull down)

		OTUB1	SLC7A11
Description		OTU deubiquitinase, ubiquitin aldehyde binding 1	solute carrier family 7 member 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Rough Endoplasmic Reticulum Cytoskeleton Plasma Membrane Cell Surface Integral Component Of Membrane Brush Border Membrane Apical Part Of Cell Astrocyte Projection
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding	Protein Binding L-amino Acid Transmembrane Transporter Activity Cystine:glutamate Antiporter Activity
	Biological Process	Adaptive Immune Response DNA Repair Cellular Response To DNA Damage Stimulus Protein K48-linked Deubiquitination Cellular Response To Interleukin-1 Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	Amino Acid Transmembrane Transport Glutathione Metabolic Process Visual Learning Response To Toxic Substance Response To Organic Cyclic Compound Ventricular System Development Striatum Development Adult Behavior Regulation Of Neutrophil Apoptotic Process Cellular Response To Oxidative Stress Glutathione Transmembrane Transport Response To Nicotine Regulation Of Cell Population Proliferation Regulation Of Melanin Biosynthetic Process Lung Alveolus Development Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Organization Regulation Of Protein Transport Response To Redox State Limb Development Lens Fiber Cell Differentiation Platelet Aggregation Glutamate Homeostasis L-glutamate Import Across Plasma Membrane Dipeptide Import Across Plasma Membrane Regulation Of Cysteine Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Glutathione Biosynthetic Process Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Glutamate Metabolic Process
Pathways		Ub-specific processing proteases Ovarian tumor domain proteases	Basigin interactions Amino acid transport across the plasma membrane
Drugs			Cystine Glutamic acid Riluzole Sulfasalazine Acetylcysteine Thimerosal
Diseases
GWAS		Bipolar disorder ( 31043756)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Mood instability ( 31168069) Neurociticism ( 29500382) Sleep duration (> 10 hours) ( 33075057)
Interacting Genes		58 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CD274 CDKN1A CPEB2 CSNK2A1 ECT2 ESR1 FOXM1 H2AX IL1RL2 KDM1A MAPT NEDD8 PACS1 PJA1 RFFL RHOA RNF126 RNF128 SLC7A11 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2S UBE2V2 UBE2Z UBE4B USP15 USP21 USP28	6 interacting genes: BAAT KRTAP1-1 KRTAP1-3 OTUB1 SLC3A2 TERT
Entrez ID		55611	23657
HPRD ID		08493	09720
Ensembl ID		ENSG00000167770	ENSG00000151012
Uniprot IDs		B3KUV5 Q96FW1	Q9UPY5
PDB IDs		2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT
Enriched GO Terms of Interacting Partners?
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