PRG2 and PAPPA

Number of citations of the paper that reports this interaction (PubMedID 10913121)
29

Data Source:
HPRD (in vitro)

		PRG2	PAPPA
Description		proteoglycan 2, pro eosinophil major basic protein	pappalysin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Transport Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Defense Response To Bacterium	Proteolysis Female Pregnancy Response To Follicle-stimulating Hormone Cellular Protein Metabolic Process Response To Glucocorticoid
Pathways		Neutrophil degranulation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Sargramostim Chymopapain	Phenethyl Isothiocyanate
Diseases
GWAS		Crohn's disease ( 22412388) Glucose homeostasis traits ( 25524916)	Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Conotruncal heart defects ( 24800985) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 28869591) Height ( 28552196 20881960 18391950) Hip circumference adjusted for BMI ( 34021172) Intralaminar thalamic nuclei volume ( 34006833) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401)
Interacting Genes		7 interacting genes: AGT AKT1 CHD3 CSF2 PAPPA PRKCZ RBM48	11 interacting genes: ATF7IP C3 CREBBP IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3
Entrez ID		5553	5069
HPRD ID		09283	01448
Ensembl ID		ENSG00000186652	ENSG00000182752
Uniprot IDs		P13727	B4DTA8 Q13219 Q7Z613
PDB IDs		1H8U 2BRS 4QXX
Enriched GO Terms of Interacting Partners?
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