PRG2 and CSF2

Number of citations of the paper that reports this interaction (PubMedID 7727786)
16

Data Source:
HPRD (in vitro)

		PRG2	CSF2
Description		proteoglycan 2, pro eosinophil major basic protein	colony stimulating factor 2
Image
GO Annotations	Cellular Component	Extracellular Region Transport Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Defense Response To Bacterium	Histamine Secretion Embryonic Placenta Development Immune Response Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Myeloid Cell Differentiation Neutrophil Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Epithelial Fluid Transport Macrophage Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Neutrophil degranulation	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling
Drugs		Sargramostim Chymopapain	KB002
Diseases
GWAS		Crohn's disease ( 22412388) Glucose homeostasis traits ( 25524916)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Rheumatoid arthritis ( 30423114 22446963 24390342) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		7 interacting genes: AGT AKT1 CHD3 CSF2 PAPPA PRKCZ RBM48	15 interacting genes: CSF2RA CSF2RB DPP7 ETF1 FBN2 IKBKE IL3RA KITLG MEOX2 P2RX7 PRG2 SDC2 SEMA7A TAGLN TREML2
Entrez ID		5553	1437
HPRD ID		09283	00734
Ensembl ID		ENSG00000186652	ENSG00000164400
Uniprot IDs		P13727	P04141
PDB IDs		1H8U 2BRS 4QXX	1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS
Enriched GO Terms of Interacting Partners?
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