SRGN and PSRC1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		SRGN	PSRC1
Description		serglycin	proline and serine rich coiled-coil 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Secretory Granule Platelet Alpha Granule Lumen Mast Cell Granule Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component	Spindle Pole Nucleoplasm Cytoplasm Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding
	Biological Process	Negative Regulation Of Cytokine Production Apoptotic Process Protein Processing Negative Regulation Of Bone Mineralization Biomineral Tissue Development Secretory Granule Organization Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Granzyme-mediated Programmed Cell Death Signaling Pathway	Microtubule Bundle Formation Mitotic Metaphase Plate Congression Negative Regulation Of Cell Growth Positive Regulation Of Microtubule Polymerization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription, DNA-templated Cell Division Regulation Of Mitotic Spindle Organization
Pathways		Platelet degranulation
Drugs
Diseases
GWAS		Glycemic traits (pregnancy) ( 23903356) Hemoglobin levels ( 32327693)	Abdominal aortic aneurysm ( 27899403) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 33730874) Blood protein levels ( 28240269) Cholesterol ( 31902109) Cholesterol, total ( 20686565) Coronary artery disease ( 32469254 29212778) Coronary heart disease ( 17634449 21378988) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) LDL cholesterol ( 18262040 18179892 18193043 18193044 19060906 19060910 21347282 20686565) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857) Low density lipoprotein cholesterol levels ( 30718733) Medication use (salicylic acid and derivatives) ( 31015401) Metabolite levels ( 21909109) Myocardial infarction (early onset) ( 19198609) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Progranulin levels ( 21087763 29186428) Response to statin therapy ( 20339536) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		17 interacting genes: ALB BAG6 CCL3 CD44 CEP70 FHL3 GZMB NCALD PEX12 PF4 PSRC1 SGTA SGTB UBQLN1 UBQLN2 UBQLN4 UBR4	4 interacting genes: APP ASB7 MAPRE3 SRGN
Entrez ID		5552	84722
HPRD ID		01513	13127
Ensembl ID		ENSG00000122862	ENSG00000134222
Uniprot IDs		P10124	A0A024R099 A8K0M8 Q6PGN9
PDB IDs
Enriched GO Terms of Interacting Partners?
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