SRGN and UBR4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		SRGN	UBR4
Description		serglycin	ubiquitin protein ligase E3 component n-recognin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Secretory Granule Platelet Alpha Granule Lumen Mast Cell Granule Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component	Nucleoplasm Centrosome Cytosol Plasma Membrane Membrane Integral Component Of Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Cytokine Production Apoptotic Process Protein Processing Negative Regulation Of Bone Mineralization Biomineral Tissue Development Secretory Granule Organization Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Granzyme-mediated Programmed Cell Death Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways		Platelet degranulation	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Verpasep caltespen PCL-016
Diseases
GWAS		Glycemic traits (pregnancy) ( 23903356) Hemoglobin levels ( 32327693)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Composite immunoglobulin trait (IgA/IgG) ( 28628107)
Interacting Genes		17 interacting genes: ALB BAG6 CCL3 CD44 CEP70 FHL3 GZMB NCALD PEX12 PF4 PSRC1 SGTA SGTB UBQLN1 UBQLN2 UBQLN4 UBR4	13 interacting genes: ADRA1A AGTR1 CALM1 ERG MTNR1A MTNR1B PRPF40A SRGN SRPK2 SUMO2 UBC UBE2D2 UBE2L3
Entrez ID		5552	23352
HPRD ID		01513	10184
Ensembl ID		ENSG00000122862	ENSG00000127481
Uniprot IDs		P10124	Q5T4S7
PDB IDs
Enriched GO Terms of Interacting Partners?
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