PTPA and RACGAP1

Number of citations of the paper that reports this interaction (PubMedID 18201571)
19

Data Source:
BioGRID (pull down, enzymatic study)

		PTPA	RACGAP1
Description		protein phosphatase 2 phosphatase activator	Rac GTPase activating protein 1
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome	Acrosomal Vesicle Nucleus Nucleoplasm Spindle Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity ATP Hydrolysis Activity Protein Phosphatase Regulator Activity Protein Homodimerization Activity Protein Phosphatase 2A Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Mitotic Spindle Organization Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Spermatogenesis Neuroblast Proliferation Sulfate Transport Positive Regulation Of Cytokinesis Intracellular Signal Transduction Regulation Of Embryonic Development Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Pathways			MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RAC3 GTPase cycle Kinesins
Drugs
Diseases
GWAS
Interacting Genes		29 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SPG21 SRC SULT4A1 TSC1	32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG
Entrez ID		5524	29127
HPRD ID		02858	05402
Ensembl ID		ENSG00000119383	ENSG00000161800
Uniprot IDs		B4DZF8 F6WIT2 Q15257	A0A024R136 B2RE34 Q9H0H5
PDB IDs		2G62 2HV6 2HV7 2IXM 4LAC 4NY3	2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K
Enriched GO Terms of Interacting Partners?
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