ARHGEF10L and SCN2A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		ARHGEF10L	SCN2A
Description		Rho guanine nucleotide exchange factor 10 like	sodium voltage-gated channel alpha subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Membrane T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding
	Biological Process	Actin Cytoskeleton Organization SREBP Signaling Pathway Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly	Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Cellular Response To Hypoxia Membrane Depolarization During Action Potential
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil
Diseases
GWAS		Basal cell carcinoma ( 18849993) Initial pursuit acceleration in psychotic disorders ( 29064472) Insomnia ( 27992416) Major depressive disorder x sex interaction ( 34099189) Obesity-related traits ( 23251661) Response to hepatitis C treatment ( 22095909)	Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Bipolar disorder ( 33263727 31043756) Diastolic blood pressure ( 30224653) Epilepsy ( 30531953) Factor VII activity ( 30642921) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Trunk fat mass ( 28552196) Urinary sodium excretion ( 31409800)
Interacting Genes		4 interacting genes: ANXA9 DRAP1 NR4A1 SCN2A	10 interacting genes: ANK3 ARHGEF10L B4GAT1 BAZ2B GALNT13 MPP3 PKP4 PLA2R1 RNF130 SCN4B
Entrez ID		55160	6326
HPRD ID		07679	03133
Ensembl ID		ENSG00000074964	ENSG00000136531
Uniprot IDs		B4DTL3 Q5VXI4 Q9HCE6	Q99250
PDB IDs			2KAV 4JPZ 4RLY 6BUT 6J8E
Enriched GO Terms of Interacting Partners?
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