NSD3 and H3-5

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (two hybrid)

		NSD3	H3-5
Description		nuclear receptor binding SET domain protein 3	H3.5 histone
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleosome Euchromatin Barr Body Nucleus
	Molecular Function	Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific) Transcription Regulator Activator Activity	Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K36 Trimethylation	Osteoblast Differentiation Nucleus Organization Spermatid Development Single Fertilization Embryo Implantation Cell Population Proliferation Male Gonad Development Positive Regulation Of Cell Growth Pericentric Heterochromatin Assembly Subtelomeric Heterochromatin Assembly Multicellular Organism Growth Muscle Cell Differentiation Oogenesis Regulation Of Centromere Complex Assembly Negative Regulation Of Chromosome Condensation
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Interacting Genes		49 interacting genes: AKT1 AP3M2 ATM BCAR3 BMP8B CASP8 CBLC CBX3 CBX5 CDKN2A CHEK2 DAXX DOCK7 E2F5 ESR1 ETV3 ETV6 FGFR4 GLIS2 GLYR1 H1-1 H3-5 H3C1 H4C1 HOXC4 IVNS1ABP LSM1 MLLT6 MNDA MYC NFIC PAX2 PPM1D RB1CC1 SEPTIN6 SLU7 SOX3 SOX4 SPAG8 SQSTM1 STAC3 TCF3 TEAD2 TERT TGFB1 TRIM55 TRIM63 UBE2I ZNF557	15 interacting genes: DAXX DNAJC9 FBLIM1 KAT6A KDM1A KDM4B NASP NSD3 PRMT5 PRMT6 PRMT7 SETMAR SMYD1 SMYD3 SUV39H1
Entrez ID		54904	440093
HPRD ID		06155	18443
Ensembl ID		ENSG00000147548	ENSG00000188375
Uniprot IDs		Q9BZ95	Q6NXT2
PDB IDs		2DAQ 2NCZ 2ND1 4GND 4GNE 4GNF 4GNG 4RXJ 5UPD 6CEN 6G24 6G25 6G27 6G29 6G2B 6G2C 6G2E 6G2F 6G2O 6G3P 6G3T 7CRP 7CRQ 7CRR	2PUY 3KV4 4Z5T 5BWN 5BWO 5F6K 5I3L 6OI3
Enriched GO Terms of Interacting Partners?
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