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SIRT1 and HNF4A
Number of citations of the paper that reports this interaction (PubMedID
15744310
)
1197
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
SIRT1
HNF4A
Description
sirtuin 1
hepatocyte nuclear factor 4 alpha
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Heterochromatin
Fibrillar Center
Nucleus
Nuclear Envelope
Nuclear Inner Membrane
Nucleoplasm
Chromatin Silencing Complex
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
PML Body
RDNA Heterochromatin
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
NAD+ ADP-ribosyltransferase Activity
Histone Deacetylase Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Nuclear Receptor Binding
NAD-dependent Histone Deacetylase Activity
Deacetylase Activity
Enzyme Binding
Protein Deacetylase Activity
NAD-dependent Protein Deacetylase Activity
Histone Binding
Identical Protein Binding
HLH Domain Binding
BHLH Transcription Factor Binding
Metal Ion Binding
NAD-dependent Histone Deacetylase Activity (H3-K9 Specific)
Mitogen-activated Protein Kinase Binding
NAD+ Binding
Protein-propionyllysine Depropionylase Activity
Keratin Filament Binding
Promoter-specific Chromatin Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Signaling Receptor Binding
Fatty Acid Binding
Protein Binding
Zinc Ion Binding
Protein Homodimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Single Strand Break Repair
Negative Regulation Of Transcription By RNA Polymerase II
RDNA Heterochromatin Assembly
Pyrimidine Dimer Repair By Nucleotide-excision Repair
DNA Synthesis Involved In DNA Repair
Angiogenesis
Ovulation From Ovarian Follicle
Cellular Glucose Homeostasis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Adaptive Immune Response
Chromatin Organization
DNA Methylation-dependent Heterochromatin Assembly
Protein ADP-ribosylation
Protein Deacetylation
Triglyceride Mobilization
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Muscle Organ Development
Cell Aging
Positive Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Negative Regulation Of Gene Expression
Regulation Of Centrosome Duplication
Positive Regulation Of Cholesterol Efflux
Regulation Of Lipid Storage
Regulation Of Glucose Metabolic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Macroautophagy
Protein Ubiquitination
Histone Deacetylation
Peptidyl-lysine Acetylation
Macrophage Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Prostaglandin Biosynthetic Process
Heterochromatin Assembly
Protein Destabilization
Negative Regulation Of TOR Signaling
Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Insulin
Circadian Regulation Of Gene Expression
Leptin-mediated Signaling Pathway
Regulation Of Smooth Muscle Cell Apoptotic Process
Peptidyl-lysine Deacetylation
Cellular Triglyceride Homeostasis
Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphorylation
Response To Hydrogen Peroxide
Behavioral Response To Starvation
Cholesterol Homeostasis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Response To Leptin
Positive Regulation Of MHC Class II Biosynthetic Process
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Gluconeogenesis
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Insulin Receptor Signaling Pathway
White Fat Cell Differentiation
Negative Regulation Of Helicase Activity
Positive Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Histone H3-K9 Methylation
Negative Regulation Of Protein Kinase B Signaling
Fatty Acid Homeostasis
Negative Regulation Of Androgen Receptor Signaling Pathway
Positive Regulation Of Macrophage Cytokine Production
Histone H3-K9 Modification
Cellular Response To Hydrogen Peroxide
Regulation Of Bile Acid Biosynthetic Process
UV-damage Excision Repair
Histone H3 Deacetylation
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Histone H3-K14 Acetylation
Cellular Response To Hypoxia
Cellular Response To Ionizing Radiation
Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Brown Fat Cell Differentiation
Stress-induced Premature Senescence
Protein Depropionylation
Regulation Of Cellular Response To Heat
Negative Regulation Of Histone H3-K9 Trimethylation
Negative Regulation Of Neuron Death
Negative Regulation Of Protein Acetylation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Adipose Tissue Development
Histone H3-K9 Deacetylation
Cellular Response To Leukemia Inhibitory Factor
Positive Regulation Of Macrophage Apoptotic Process
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Negative Regulation Of Histone H4-K16 Acetylation
Negative Regulation Of Cellular Response To Testosterone Stimulus
Negative Regulation Of Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Cellular Senescence
Type B Pancreatic Cell Development
Regulation Of Transcription By RNA Polymerase II
Ornithine Metabolic Process
Lipid Metabolic Process
Xenobiotic Metabolic Process
Sex Differentiation
Blood Coagulation
Negative Regulation Of Cell Population Proliferation
Response To Glucose
Regulation Of Gastrulation
Regulation Of Lipid Metabolic Process
Signal Transduction Involved In Regulation Of Gene Expression
Cell Differentiation
Negative Regulation Of Cell Growth
Intracellular Receptor Signaling Pathway
Glucose Homeostasis
Cholesterol Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Anatomical Structure Development
Regulation Of Insulin Secretion
Lipid Homeostasis
Phospholipid Homeostasis
SMAD Protein Signal Transduction
Triglyceride Homeostasis
Hepatocyte Differentiation
Pathways
Regulation of HSF1-mediated heat shock response
Circadian Clock
SIRT1 negatively regulates rRNA expression
SIRT1 negatively regulates rRNA expression
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
Heme signaling
Nuclear Receptor transcription pathway
Drugs
Resveratrol
Selisistat
Cambinol
Lauric acid
AVI-4557
Myristic acid
Diseases
GWAS
Atrial fibrillation (
30061737
)
Chronotype (
30696823
)
Diverticular disease (
30177863
)
Molybdenum levels (
26025379
)
Pulse pressure (
30224653
)
Apolipoprotein A1 levels (
32203549
)
Apolipoprotein B levels (
32203549
)
C-reactive protein (
22939635
)
C-reactive protein levels (
30388399
21300955
)
C-reactive protein levels or HDL-cholesterol levels (pleiotropy) (
27286809
)
C-reactive protein levels or LDL-cholesterol levels (pleiotropy) (
27286809
)
C-reactive protein levels or total cholesterol levels (pleiotropy) (
27286809
)
Cholesterol, total (
24097068
20686565
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Coenzyme Q10 levels (
27149984
)
Estimated glomerular filtration rate (
31152163
)
Factor VII activity (
30642921
)
Fibrinogen levels (
28107422
26561523
)
Gallstone disease (
30504769
)
Granulocyte count (
27863252
)
HDL cholesterol (
24097068
19060906
30275531
25961943
20686565
)
HDL cholesterol levels (
32203549
30698716
)
HDL cholesterol levels in current drinkers (
30698716
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x long total sleep time interaction (2df test) (
31719535
)
HDL cholesterol levels x short total sleep time interaction (2df test) (
31719535
)
Hematocrit (
32888494
27863252
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
High density lipoprotein cholesterol levels (
33339817
)
LDL cholesterol levels (
32203549
)
LDL cholesterol levels in current drinkers (
30698716
)
LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Low density lipoprotein cholesterol levels (
32154731
)
Lymphocyte percentage of white cells (
32888494
)
Medication use (drugs used in diabetes) (
31015401
)
Metabolic syndrome (
31589552
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
27863252
)
Pancreatic cancer (
29422604
)
Red blood cell count (
32888494
)
Serum uric acid levels (
30993211
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Total cholesterol levels (
33339817
)
Type 2 diabetes (
24509480
30054458
21874001
30297969
29632382
31118516
32499647
22158537
30718926
28869590
)
Type 2 diabetes (adjusted for BMI) (
29632382
)
Ulcerative colitis (
19915572
23128233
)
Urate levels (
31578528
)
White blood cell count (
32888494
)
Interacting Genes
65 interacting genes:
AFP
AKT1
AR
ARNTL
BAZ1B
BCL11A
BHLHE41
BRIP1
CDK6
CENATAC
CHFR
CLOCK
CSNK2B
CTTN
E2F1
EP300
ESRRA
EZH2
FOS
FOXM1
FOXO1
FOXO3
GAPDH
H1-5
H3C1
HES1
HEY2
HIC1
HIPK2
HNF4A
HOXB9
MAPK8
MPHOSPH8
MYCN
NBN
NDN
NMNAT1
NR1H2
NR1H3
NR1H4
PARP1
PML
PPARA
PPARG
PPARGC1A
PRMT1
PSME3
RARA
RELA
RICTOR
RRP8
SATB1
SETD7
SMAD7
SMURF2
SNW1
STK11
STK4
SUMO2
TP53
TP73
TRIM28
UBE2I
USP22
VDR
69 interacting genes:
ANP32B
ARNT
COPS5
CREBBP
DDX3X
DMD
EIF1AY
ESR1
FOXO1
GTF2B
GTF2H1
HDAC3
HDAC4
HIF1A
HNF1A
ISL1
MAPK1
MAPK14
MAPK3
MECR
MED1
MED10
MED14
MED16
MED17
MED21
MED24
MED7
NCOA1
NCOA2
NCOA6
NCOR2
NPPA
NR0B2
NR1I2
NR1I3
NR2C2
NR2F1
NRBF2
NRIP1
PCBD1
PIAS4
PLPP2
PNRC1
PNRC2
PPARGC1A
PPARGC1B
PRKAA2
PRKACA
PRMT1
PROX1
RNF4
SIRT1
SMAD2
SMAD3
SMAD4
SP1
SREBF1
SREBF2
SUB1
TAF6
TAF9
TBP
TGS1
TP53
TRIM24
UBE2I
XPO1
ZNHIT3
Entrez ID
23411
3172
HPRD ID
08381
02612
Ensembl ID
ENSG00000096717
ENSG00000101076
Uniprot IDs
A0A024QZQ1
A8K128
B0QZ35
E9PC49
Q96EB6
A0A087WXV4
B9VVT8
F1D8S2
F1D8T0
F1D8T1
P41235
PDB IDs
4I5I
4IF6
4IG9
4KXQ
4ZZH
4ZZI
4ZZJ
5BTR
1PZL
3CBB
3FS1
4B7W
4IQR
6CHT
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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