KIR2DL4 and RNF216

Number of citations of the paper that reports this interaction (PubMedID 21270397)
15

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		KIR2DL4	RNF216
Description		killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	ring finger protein 216
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Early Endosome Membrane	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class Ib Receptor Activity	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Cellular Defense Response Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cellular Senescence	Apoptotic Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Objective response to lithium treatment ( 26503763)	Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)
Interacting Genes		9 interacting genes: BPIFA1 FCER1G FHL5 HLA-G INCA1 RBPMS RNF216 TIMMDC1 TRIP6	30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A
Entrez ID		3805	54476
HPRD ID		16082	15550
Ensembl ID		ENSG00000189013	ENSG00000011275
Uniprot IDs		A0A0B4J1S6 A0A376A929 Q99706	A8K8N1 Q9NWF9
PDB IDs		3WYR
Enriched GO Terms of Interacting Partners?
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