TLR9 and RNF216

Number of citations of the paper that reports this interaction (PubMedID 15107846)
122

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TLR9	RNF216
Description		toll like receptor 9	ring finger protein 216
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Early Phagosome Endolysosome Endolysosome Membrane	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	NAD+ Nucleosidase Activity Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding SiRNA Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity Unmethylated CpG Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Toll-like Receptor Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of Immunoglobulin Production MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Positive Regulation Of Gene Expression Maintenance Of Gastrointestinal Epithelium Positive Regulation Of B Cell Proliferation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Toll-like Receptor 9 Signaling Pathway Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Innate Immune Response Regulation Of B Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity	Apoptotic Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission
Pathways		PI3K Cascade Trafficking and processing of endosomal TLR Toll Like Receptor 9 (TLR9) Cascade Potential therapeutics for SARS TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome	Negative regulators of DDX58/IFIH1 signaling
Drugs		Chloroquine Hydroxychloroquine ISS-1018 Golotimod CPG 10101
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Body shape index ( 34021172) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) Feeling nervous ( 29500382) General cognitive ability ( 29844566) Parkinson's disease ( 28892059) Schizophrenia ( 23974872) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)
Interacting Genes		6 interacting genes: BTK HRAS MAPK8IP3 RNF216 SIGIRR TLR1	30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A
Entrez ID		54106	54476
HPRD ID		05685	15550
Ensembl ID		ENSG00000239732	ENSG00000011275
Uniprot IDs		Q9NR96	A8K8N1 Q9NWF9
PDB IDs
Enriched GO Terms of Interacting Partners?
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