ATP7A and CP

Number of citations of the paper that reports this interaction (PubMedID 11040994)
1

Data Source:
HPRD (in vitro)

		ATP7A	CP
Description		ATPase copper transporting alpha	ceruloplasmin
Image
GO Annotations	Cellular Component	Nucleus Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Microvillus Postsynaptic Density Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Axon Dendrite Phagocytic Vesicle Membrane Cell Leading Edge Brush Border Membrane Early Endosome Membrane Trans-Golgi Network Membrane Melanosome Membrane Neuron Projection Neuronal Cell Body Perikaryon Membrane Raft Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding Superoxide Dismutase Copper Chaperone Activity ATP Hydrolysis Activity Small GTPase Binding Copper-dependent Protein Binding P-type Divalent Copper Transporter Activity Chaperone Binding P-type Monovalent Copper Transporter Activity Cuprous Ion Binding	Ferroxidase Activity Copper Ion Binding Oxidoreductase Activity Chaperone Binding
	Biological Process	Blood Vessel Development In Utero Embryonic Development Liver Development Blood Vessel Remodeling Regulation Of Oxidative Phosphorylation Tryptophan Metabolic Process Catecholamine Metabolic Process Copper Ion Transport Cellular Copper Ion Homeostasis Mitochondrion Organization Female Pregnancy Lactation Locomotory Behavior Response To Iron(III) Ion Response To Manganese Ion Response To Zinc Ion Detoxification Of Copper Ion Regulation Of Gene Expression Positive Regulation Of Lamellipodium Assembly Copper Ion Import Peptidyl-lysine Modification Removal Of Superoxide Radicals Cerebellar Purkinje Cell Differentiation Pyramidal Neuron Development Central Nervous System Neuron Development Extracellular Matrix Organization Collagen Fibril Organization Hair Follicle Morphogenesis Positive Regulation Of Tyrosinase Activity Negative Regulation Of Iron Ion Transmembrane Transport Cellular Response To Platelet-derived Growth Factor Stimulus T-helper Cell Differentiation Epinephrine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Serotonin Metabolic Process Positive Regulation Of Catalytic Activity Pigmentation Skin Development Positive Regulation Of Cell Size Positive Regulation Of Melanin Biosynthetic Process Elastic Fiber Assembly Lung Alveolus Development Neuron Projection Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Positive Regulation Of Oxidoreductase Activity Elastin Biosynthetic Process Copper Ion Homeostasis Copper Ion Export Cellular Response To Amino Acid Stimulus Cellular Response To Antibiotic Cellular Response To Cadmium Ion Cellular Response To Cobalt Ion Cellular Response To Copper Ion Cellular Response To Iron Ion Cellular Response To Lead Ion Cellular Response To Hypoxia Positive Regulation Of Response To Wounding Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Cytochrome-c Oxidase Activity	Copper Ion Transport Iron Ion Transport Cellular Iron Ion Homeostasis Iron Ion Homeostasis
Pathways		Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface Ion transport by P-type ATPases	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Post-translational protein phosphorylation Iron uptake and transport
Drugs			Calcium Iron Zinc Silver Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Height ( 31562340)	Subcutaneous adipose tissue ( 22589738)
Interacting Genes		3 interacting genes: ATOX1 CP PDZD11	8 interacting genes: ATP7A BTRC GAST HSP90AA1 LTF MPO PLG PROC
Entrez ID		538	1356
HPRD ID		02054	00317
Ensembl ID		ENSG00000165240	ENSG00000047457
Uniprot IDs		B4DRW0 Q04656 Q762B6	A5PL27 P00450
PDB IDs		1AW0 1KVI 1KVJ 1Q8L 1S6O 1S6U 1Y3J 1Y3K 1YJR 1YJT 1YJU 1YJV 2AW0 2G9O 2GA7 2K1R 2KIJ 2KMV 2KMX 3CJK 5T7L	1KCW 2J5W 4EJX 4ENZ
Enriched GO Terms of Interacting Partners?
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