PMP22 and CLEC12B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PMP22	CLEC12B
Description		peripheral myelin protein 22	C-type lectin domain family 12 member B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Compact Myelin Synapse	External Side Of Plasma Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Protein Binding	Protein Phosphatase Binding Carbohydrate Binding Signaling Receptor Inhibitor Activity
	Biological Process	Chemical Synaptic Transmission Peripheral Nervous System Development Cell Death Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Bleb Assembly Myelin Assembly	Natural Killer Cell Inhibitory Signaling Pathway Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Signaling Receptor Activity
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 29566793) Corneal structure ( 23291589) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)	Malaria ( 31844061) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Systolic blood pressure in sickle cell anemia ( 24058526)
Interacting Genes		59 interacting genes: APOL3 ARL13B ASGR2 ATP6AP2 C16orf54 CANX CD3G CD53 CD69 CEACAM3 CLDN18 CLDN5 CLDN6 CLEC12B CLEC14A CREB3 CREB3L1 DDX52 EBP EDA EMP1 ERGIC3 FAM209A FCGRT FFAR2 GJA8 GPR42 GPR61 GPRC5D IFNGR2 KCNJ6 KCNN4 KLRC1 LMNA MPZ MS4A7 OPRM1 PDZK1IP1 PEX19 PGRMC2 REEP4 SCN3B SDC4 SHISAL1 SLC18A1 SLC38A1 SMIM3 SPACA1 STOM SYT2 TLCD4 TM4SF18 TM4SF19 TMEM139 TMEM14B TMEM30B TMEM31 TMX1 TSPAN12	11 interacting genes: IL1RL1 JAGN1 LPAR3 LSMEM2 MALL OPRM1 PLLP PMP22 SCD SEC22A VMA21
Entrez ID		5376	387837
HPRD ID		03059	18266
Ensembl ID		ENSG00000109099	ENSG00000256660
Uniprot IDs		A8MU75 Q01453 Q6FH25	A0A140VK10 Q2HXU8
PDB IDs
Enriched GO Terms of Interacting Partners?
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