FXYD1 and ATP1B1

Number of citations of the paper that reports this interaction (PubMedID 14597563)
38

Data Source:
HPRD (in vivo)

		FXYD1	ATP1B1
Description		FXYD domain containing ion transport regulator 1	ATPase Na+/K+ transporting subunit beta 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Apical Plasma Membrane T-tubule Sarcolemma	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Sperm Flagellum Sarcolemma Extracellular Exosome Extracellular Vesicle
	Molecular Function	Chloride Channel Activity Sodium Channel Regulator Activity Transmembrane Transporter Binding	ATPase Activator Activity P-type Sodium:potassium-exchanging Transporter Activity Protein Binding Protein C-terminus Binding Protein Kinase Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity ATPase Binding
	Biological Process	Potassium Ion Transport Sodium Ion Transport Chloride Transport Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Protein Glutathionylation Regulation Of Cardiac Muscle Cell Membrane Potential Positive Regulation Of Sodium Ion Export Across Plasma Membrane Regulation Of Sodium Ion Transmembrane Transporter Activity	Response To Hypoxia Cellular Calcium Ion Homeostasis Cellular Sodium Ion Homeostasis Cell Adhesion Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Potassium Ion Homeostasis Positive Regulation Of ATPase Activity Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Transport Into Plasma Membrane Raft ATP Metabolic Process Regulation Of Catalytic Activity Protein Stabilization Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Protein Localization To Plasma Membrane Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cation Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Calcium:sodium Antiporter Activity Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of P-type Sodium:potassium-exchanging Transporter Activity Potassium Ion Import Across Plasma Membrane
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 25055868) Electrocardiographic traits (multivariate) ( 32602732) Fuchs's corneal dystrophy ( 28358029) Haemorrhoidal disease ( 33888516) Keratoconus ( 33649486) Mitochondrial DNA levels ( 25240745) QT interval ( 23166209 29213071 24952745 19305409 29874175) Rosacea symptom severity ( 29771307)
Interacting Genes		9 interacting genes: ATP1A1 ATP1B1 DMPK PAM PLPP1 PPP1CA PRKACA SLC8A1 YWHAQ	29 interacting genes: AGTR1 BACE1 BARD1 BRCA1 CD84 CREG1 CRIP2 DDAH2 EGFR EZH2 FXYD1 FXYD7 GCH1 HCRTR1 HTR2B KMT2B LRIF1 NDRG2 OGT PAXIP1 PRRX1 PSME1 SERPINC1 THOC1 TM4SF1 TRIM14 TRMT2A TSC22D2 USP4
Entrez ID		5348	481
HPRD ID		03837	01663
Ensembl ID		ENSG00000266964	ENSG00000143153
Uniprot IDs		O00168	A3KLL5 P05026
PDB IDs		2J1I 2JO1
Enriched GO Terms of Interacting Partners?
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