UBASH3A and KRT14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		UBASH3A	KRT14
Description		ubiquitin associated and SH3 domain containing A	keratin 14
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Extracellular Exosome	Nucleus Cytoplasm Cytosol Intermediate Filament Keratin Filament Basal Part Of Cell Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Keratin Filament Binding
	Biological Process	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway	Aging Epidermis Development Response To Zinc Ion Response To Ionizing Radiation Epithelial Cell Differentiation Hair Cycle Intermediate Filament Bundle Assembly
Pathways			Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases
GWAS		Addison's disease ( 33574239) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Medication use (thyroid preparations) ( 31015401) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 21829393 25751624 19430480 30572963 18840781) Vitiligo ( 20410501 27723757)
Interacting Genes		92 interacting genes: ARRDC1 ARRDC3 BACE2 BCAR3 C9orf24 CBLB CBS CCDC33 CD3E COPS9 DAZAP2 DDIT4L DISC1 DLGAP4 DNM2 DTX3 FADS6 FAM83A FGFR1OP2 GFAP GOLGA6L9 HSP90AA1 HSP90B1 HSPD1 IKBKG ISY1-RAB43 KCNE1 KCTD1 KIAA0408 KPRP KRT14 KRT31 KRT32 KRT35 KRT39 KRT40 LCN2 LNX1 LZTS1 LZTS2 MAP3K7 MKRN1 N4BP3 NSMF PLEKHB2 PMEPA1 PNMA5 PRDM6 PRKN PSMC1 PSMC4 REL RNF216 RNF41 SF3B4 SH3RF1 SHISA6 SLA2 SLC37A1 SNRNP48 SOS1 SPRY1 SPRY2 STX11 TAX1BP1 TEKT1 TEKT4 TIMM44 TMCO2 TMEM239 TP53BP2 TP63 TRIM27 TRIM37 TRIM5 TRIM50 TRIM8 TUBB8 TYR UBB UBC UBE2L3 VCP VPS37B WAS WASL WBP11 ZBTB42 ZC2HC1C ZNF219 ZNF474 ZRANB1	32 interacting genes: ABI2 ABI3 AMOT APC BFSP2 CTTNBP2 DST ENKD1 GAS8 HGS HSPA5 KIFC3 KRT1 KRT3 KRT5 KRT6C KRT72 KRT78 KRT79 KRT80 KRT81 KRT86 OIP5 PKP1 PRPH PUS10 SDCBP SMARCE1 TCHP TRADD UBASH3A USHBP1
Entrez ID		53347	3861
HPRD ID		06904	01017
Ensembl ID		ENSG00000160185	ENSG00000186847
Uniprot IDs		P57075	P02533
PDB IDs		2CRN 5WDI	3TNU 6JFV
Enriched GO Terms of Interacting Partners?
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