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UBASH3A and SPRY2
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
484
Data Source:
BioGRID
(two hybrid, two hybrid, two hybrid)
UBASH3A
SPRY2
Description
ubiquitin associated and SH3 domain containing A
sprouty RTK signaling antagonist 2
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Extracellular Exosome
Nucleus
Cytosol
Cytoskeleton
Plasma Membrane
Actin Cytoskeleton
Microtubule Cytoskeleton
Membrane
Ruffle Membrane
Microtubule End
Molecular Function
Protein Binding
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Biological Process
Regulation Of Cytokine Production
Negative Regulation Of T Cell Receptor Signaling Pathway
Establishment Of Mitotic Spindle Orientation
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Angiogenesis
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Projection Organization
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of GTPase Activity
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Cell Fate Commitment
Negative Regulation Of Ras Protein Signal Transduction
Animal Organ Development
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Lung Growth
Bud Elongation Involved In Lung Branching
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Lens Fiber Cell Differentiation
Cellular Response To Leukemia Inhibitory Factor
Pathways
Spry regulation of FGF signaling
EGFR downregulation
Drugs
Diseases
GWAS
Addison's disease (
33574239
)
Asthma (
32296059
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
30572963
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Diverticular disease (
30177863
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte counts (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Primary sclerosing cholangitis (
27992413
)
Rheumatoid arthritis (
30423114
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Type 1 diabetes (
21829393
25751624
19430480
30572963
18840781
)
Vitiligo (
20410501
27723757
)
Adiposity (
21706003
)
Adventurousness (
30643258
)
Body fat percentage (
26833246
)
Central corneal thickness (
32528159
)
Cleft lip with or without cleft palate (
28054174
)
Diastolic blood pressure (
30224653
)
Fasting blood insulin (BMI interaction) (
22581228
)
General risk tolerance (MTAG) (
30643258
)
Height (
25282103
31562340
)
Insulin-related traits (multivariate analysis) (
32002517
)
Lactose tolerance test (
31791255
)
Leisure-time exercise behaviour (age-stratified) (
30102679
)
Medication use (drugs used in diabetes) (
31015401
)
Methadone dose in opioid dependence (
28115739
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Orofacial clefts (
20023658
22863734
28054174
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Sleep duration (
25469926
)
Thrombocytopenia in coronary artery bypass surgery (
30103242
)
Type 2 diabetes (
22885922
24509480
30054458
20862305
29358691
30297969
26818947
31118516
32499647
30718926
28869590
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Interacting Genes
92 interacting genes:
ARRDC1
ARRDC3
BACE2
BCAR3
C9orf24
CBLB
CBS
CCDC33
CD3E
COPS9
DAZAP2
DDIT4L
DISC1
DLGAP4
DNM2
DTX3
FADS6
FAM83A
FGFR1OP2
GFAP
GOLGA6L9
HSP90AA1
HSP90B1
HSPD1
IKBKG
ISY1-RAB43
KCNE1
KCTD1
KIAA0408
KPRP
KRT14
KRT31
KRT32
KRT35
KRT39
KRT40
LCN2
LNX1
LZTS1
LZTS2
MAP3K7
MKRN1
N4BP3
NSMF
PLEKHB2
PMEPA1
PNMA5
PRDM6
PRKN
PSMC1
PSMC4
REL
RNF216
RNF41
SF3B4
SH3RF1
SHISA6
SLA2
SLC37A1
SNRNP48
SOS1
SPRY1
SPRY2
STX11
TAX1BP1
TEKT1
TEKT4
TIMM44
TMCO2
TMEM239
TP53BP2
TP63
TRIM27
TRIM37
TRIM5
TRIM50
TRIM8
TUBB8
TYR
UBB
UBC
UBE2L3
VCP
VPS37B
WAS
WASL
WBP11
ZBTB42
ZC2HC1C
ZNF219
ZNF474
ZRANB1
109 interacting genes:
ADAMTSL4
AQP1
ATRIP
BAG3
BRAF
CATSPER1
CBL
CBLB
CBLC
CHRD
CHRNG
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
EIF4E2
FAIM
FAM219A
FBN1
FBXO7
FRS3
FXR1
FXR2
GNE
GP9
GPRIN2
GRAP2
GRB2
GRN
HEXIM2
HNRNPLL
HOXA1
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1A
LCE1B
LCE1C
LCE1F
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MB21D2
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NDFIP2
NEDD4
NR1H2
NUBP1
NUFIP2
OTX1
PACSIN3
PLSCR1
PRKAB2
PRKCD
PRKD1
PTGER3
PTPN11
RAF1
RTF2
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SHFL
SIAH2
SPRY1
STK16
TCAF1
TMEM14B
TNS2
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
Entrez ID
53347
10253
HPRD ID
06904
03916
Ensembl ID
ENSG00000160185
ENSG00000136158
Uniprot IDs
P57075
O43597
PDB IDs
2CRN
5WDI
3BUM
3OB1
5HKY
5HKZ
5HL0
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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