PIK3CA and TRA2B

		PIK3CA	TRA2B
Description		phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	transformer 2 beta homolog
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Complex, Class IB Intercalated Disc Membrane Lamellipodium Perinuclear Region Of Cytoplasm	Nucleus Nuclear Inner Membrane Nucleoplasm Spliceosomal Complex Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity Protein Serine Kinase Activity	RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Pre-mRNA Binding Identical Protein Binding
	Biological Process	Angiogenesis Liver Development Vasculature Development Glucose Metabolic Process Protein Phosphorylation Phagocytosis Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Lamellipodium Assembly Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Macroautophagy Phosphorylation Cell Migration Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Actin Filament Depolymerization T Cell Costimulation Positive Regulation Of TOR Signaling Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Response To Muscle Stretch Phosphatidylinositol-3-phosphate Biosynthetic Process Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Multicellular Organism Growth Anoikis Regulation Of Cellular Respiration Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Hypomethylation Of CpG Island Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Adipose Tissue Development Cellular Response To Glucose Stimulus Cellular Response To Hydrostatic Pressure Cardiac Muscle Cell Contraction Energy Homeostasis Regulation Of Actin Filament Organization Negative Regulation Of Fibroblast Apoptotic Process Regulation Of Genetic Imprinting Negative Regulation Of Anoikis	Response To Reactive Oxygen Species RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Cerebral Cortex Regionalization Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Response To Glucose Stimulus Embryonic Brain Development
Pathways		PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K events in ERBB4 signaling PIP3 activates AKT signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane GAB1 signalosome Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction PI3K events in ERBB2 signaling PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling Extra-nuclear estrogen signaling RAC1 GTPase cycle RAC2 GTPase cycle Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Activated NTRK3 signals through PI3K FLT3 Signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by ALK fusions and activated point mutants	mRNA Splicing - Major Pathway RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs		ATP Caffeine XL765 Wortmannin Pilaralisib Alpelisib Copanlisib
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494)	Height ( 31562340) Menarche (age at onset) ( 27182965 21102462 25231870) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		78 interacting genes: ACOT8 ADAP1 AKT1 ALCAM AMBP APLP2 APPL1 ARAF ATP5IF1 ATR BEX1 BEX2 CCND2 CRIP1 CSF1R CYTH2 CYTH3 DDX5 DNAJB6 EGFR FANCC FASLG FBP2 FTL GABRB1 GALNT12 GLIS2 GNAQ GRIN2B HRAS IL13RA2 IL24 IL3 IRS2 IRS4 ITIH1 KRAS LCK LYPLA1 MAP2K1 MAP3K9 MRAS MYC NEDD4L NEDD9 NRAS PDGFRA PDGFRB PDK1 PIK3R1 PIK3R3 PRKCD PRKCI PSMC3IP PTPN11 RASD2 RASGRP3 RELA RHOC RPS20 RPS6KB1 SFRP4 SGK1 SH3KBP1 SMAD2 SMAD3 SNX9 SQSTM1 STAT1 STK11 THRSP TICAM1 TMOD1 TNFSF13 TRA2B UFD1 UMPS VARS2	110 interacting genes: - CDK6 CLK1 CLK3 EPM2AIP1 HINFP HIPK3 HNRNPA1 IVNS1ABP LUM MAGOHB MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYPOP NGFR NXF1 PCDHB14 PIK3CA RBMX RBMXL2 RBMY1A1 RBMY1F RBMY1J RNPS1 SREK1 SRPK1 SRPK2 SRSF10 SRSF2 SRSF3 SRSF4 SRSF8 SRSF9 TNPO3 U2AF1 USP13 YTHDC1 YWHAG YWHAZ ZRANB2
Entrez ID		5290	6434
HPRD ID		01382	04097
Ensembl ID		ENSG00000121879	ENSG00000136527
Uniprot IDs		P42336 Q4LE51	P62995
PDB IDs		2ENQ 2RD0 3HHM 3HIZ 3ZIM 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4TUU 4TV3 4WAF 4YKN 4ZOP 5DXH 5DXT 5FI4 5ITD 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBR 5UK8 5UKJ 5UL1 5XGH 5XGI 5XGJ 6GVF 6GVG 6GVH 6GVI 6NCT 6OAC 6PYS 6VO7 7K6M 7K6N 7K6O 7K71	2CQC 2KXN 2RRA 2RRB
Enriched GO Terms of Interacting Partners?
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