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PIK3CA and SFRP4
Number of citations of the paper that reports this interaction (PubMedID
24412244
)
2
Data Source:
BioGRID
(two hybrid)
PIK3CA
SFRP4
Description
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
secreted frizzled related protein 4
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Phosphatidylinositol 3-kinase Complex, Class IB
Intercalated Disc
Membrane
Lamellipodium
Perinuclear Region Of Cytoplasm
Extracellular Space
Nucleus
Cytoplasm
Cell Surface
Molecular Function
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Protein Kinase Activator Activity
Phosphatidylinositol 3-kinase Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
Insulin Receptor Substrate Binding
Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Phosphatidylinositol Kinase Activity
Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
Protein Serine Kinase Activity
Protein Binding
Wnt-protein Binding
Biological Process
Angiogenesis
Liver Development
Vasculature Development
Glucose Metabolic Process
Protein Phosphorylation
Phagocytosis
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Gene Expression
Positive Regulation Of Lamellipodium Assembly
Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Macroautophagy
Phosphorylation
Cell Migration
Actin Cytoskeleton Organization
Platelet Activation
Negative Regulation Of Actin Filament Depolymerization
T Cell Costimulation
Positive Regulation Of TOR Signaling
Activation Of Protein Kinase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Response To Muscle Stretch
Phosphatidylinositol-3-phosphate Biosynthetic Process
Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase
Vascular Endothelial Growth Factor Signaling Pathway
Regulation Of Multicellular Organism Growth
Anoikis
Regulation Of Cellular Respiration
Protein Kinase B Signaling
Negative Regulation Of Neuron Apoptotic Process
Endothelial Cell Migration
Hypomethylation Of CpG Island
Phosphatidylinositol Phosphate Biosynthetic Process
Phosphatidylinositol-mediated Signaling
T Cell Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Relaxation Of Cardiac Muscle
Cardiac Muscle Contraction
Adipose Tissue Development
Cellular Response To Glucose Stimulus
Cellular Response To Hydrostatic Pressure
Cardiac Muscle Cell Contraction
Energy Homeostasis
Regulation Of Actin Filament Organization
Negative Regulation Of Fibroblast Apoptotic Process
Regulation Of Genetic Imprinting
Negative Regulation Of Anoikis
Positive Regulation Of Receptor Internalization
Negative Regulation Of Cell Population Proliferation
Response To Hormone
Positive Regulation Of Gene Expression
Cell Differentiation
Negative Regulation Of Wnt Signaling Pathway
Regulation Of BMP Signaling Pathway
Non-canonical Wnt Signaling Pathway
Positive Regulation Of Apoptotic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Epidermal Cell Differentiation
Phosphate Ion Homeostasis
Canonical Wnt Signaling Pathway
Bone Morphogenesis
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Keratinocyte Apoptotic Process
Negative Regulation Of Non-canonical Wnt Signaling Pathway
Negative Regulation Of Sodium-dependent Phosphate Transport
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
RET signaling
Extra-nuclear estrogen signaling
RAC1 GTPase cycle
RAC2 GTPase cycle
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Activated NTRK3 signals through PI3K
FLT3 Signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by ALK fusions and activated point mutants
Drugs
ATP
Caffeine
XL765
Wortmannin
Pilaralisib
Alpelisib
Copanlisib
Cyclothiazide
Perindopril
Diseases
GWAS
Mean corpuscular hemoglobin (
29403010
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Blood protein levels (
30072576
)
Dupuytren's disease (
28886342
21732829
)
ghrelin levels (
33852427
)
Heel bone mineral density (
30598549
28869591
)
Interacting Genes
78 interacting genes:
ACOT8
ADAP1
AKT1
ALCAM
AMBP
APLP2
APPL1
ARAF
ATP5IF1
ATR
BEX1
BEX2
CCND2
CRIP1
CSF1R
CYTH2
CYTH3
DDX5
DNAJB6
EGFR
FANCC
FASLG
FBP2
FTL
GABRB1
GALNT12
GLIS2
GNAQ
GRIN2B
HRAS
IL13RA2
IL24
IL3
IRS2
IRS4
ITIH1
KRAS
LCK
LYPLA1
MAP2K1
MAP3K9
MRAS
MYC
NEDD4L
NEDD9
NRAS
PDGFRA
PDGFRB
PDK1
PIK3R1
PIK3R3
PRKCD
PRKCI
PSMC3IP
PTPN11
RASD2
RASGRP3
RELA
RHOC
RPS20
RPS6KB1
SFRP4
SGK1
SH3KBP1
SMAD2
SMAD3
SNX9
SQSTM1
STAT1
STK11
THRSP
TICAM1
TMOD1
TNFSF13
TRA2B
UFD1
UMPS
VARS2
22 interacting genes:
AP2M1
AQP6
AURKA
BMPR1A
BUB1
CDKN2A
CKMT1B
CTNNA1
DLC1
ERBB2
FADS2
HSD17B11
MCC
NARF
NRAS
PDGFRL
PFKM
PIK3CA
PMS2
PTPN12
PTPRJ
SMAD4
Entrez ID
5290
6424
HPRD ID
01382
07357
Ensembl ID
ENSG00000121879
ENSG00000106483
Uniprot IDs
P42336
Q4LE51
Q6FHJ7
PDB IDs
2ENQ
2RD0
3HHM
3HIZ
3ZIM
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4TUU
4TV3
4WAF
4YKN
4ZOP
5DXH
5DXT
5FI4
5ITD
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBR
5UK8
5UKJ
5UL1
5XGH
5XGI
5XGJ
6GVF
6GVG
6GVH
6GVI
6NCT
6OAC
6PYS
6VO7
7K6M
7K6N
7K6O
7K71
Enriched GO Terms of Interacting Partners
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