PGF and NRP2

Number of citations of the paper that reports this interaction (PubMedID 10748121)
99

Data Source:
HPRD (in vivo)

		PGF	NRP2
Description		placental growth factor	neuropilin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane Axon Glutamatergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Protein-containing Complex Binding	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Female Pregnancy Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Cell Differentiation Animal Organ Regeneration Cellular Response To Hormone Stimulus Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Septum Morphogenesis Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Facial Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Trigeminal Ganglion Development Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Cellular Response To Leukemia Inhibitory Factor
Pathways		VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization	Neurophilin interactions with VEGF and VEGFR NrCAM interactions
Drugs		Aflibercept
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Mood instability ( 29187730) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301)	Blood protein levels ( 30072576 29875488) Craniofacial microsomia ( 26853712) Daytime nap ( 33568662) Diisocyanate-induced asthma ( 25918132) Neuropathy x type 2 diabetes interaction ( 32541925)
Interacting Genes		4 interacting genes: FLT1 NRP1 NRP2 VEGFA	11 interacting genes: FLT1 L1CAM NRP1 PGF PLXNA1 PLXNB1 SEMA3B SEMA3C SEMA3F SEMA4F VEGFA
Entrez ID		5228	8828
HPRD ID		03076	03643
Ensembl ID		ENSG00000119630	ENSG00000118257
Uniprot IDs		G3XA84 P49763 Q53XY6 Q86TW6	O60462 Q7Z3T9
PDB IDs		1FZV 1RV6	2QQJ 2QQK 2QQL 2QQO 4QDQ 4QDR 4QDS 5DN2 5DQ0 6GH8 6TDB 6TJT
Enriched GO Terms of Interacting Partners?
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