NRP2 and SEMA3C

Number of citations of the paper that reports this interaction (PubMedID 9331348)
165

Data Source:
HPRD (in vivo)

		NRP2	SEMA3C
Description		neuropilin 2	semaphorin 3C
Image			No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane Axon Glutamatergic Synapse Integral Component Of Postsynaptic Membrane	Extracellular Space Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding	Semaphorin Receptor Binding Chemorepellent Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Septum Morphogenesis Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Facial Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Trigeminal Ganglion Development Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Cellular Response To Leukemia Inhibitory Factor	Neural Crest Cell Migration Somitogenesis Blood Vessel Remodeling Outflow Tract Septum Morphogenesis Cardiac Right Ventricle Morphogenesis Pulmonary Myocardium Development Immune Response Axon Guidance Response To Xenobiotic Stimulus Post-embryonic Development Neural Tube Development Positive Regulation Of Cell Migration Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Limb Bud Formation Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Cardiac Endothelial To Mesenchymal Transition Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Pathways		Neurophilin interactions with VEGF and VEGFR NrCAM interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Craniofacial microsomia ( 26853712) Daytime nap ( 33568662) Diisocyanate-induced asthma ( 25918132) Neuropathy x type 2 diabetes interaction ( 32541925)	Bilirubin levels ( 19414484) Blood protein levels ( 30072576 29875488) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Diastolic blood pressure ( 27841878) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 33627673 29891935) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) HDL cholesterol ( 27036123) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 33339817) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29617998 31959993 30054594 29235454) Metabolite levels ( 23823483) Posterior cortical atrophy and Alzheimer's disease ( 26993346) Red blood cell count ( 32888494) Resistance to antihypertensive treatment in hypertension ( 31545351) Rosacea symptom severity ( 29771307) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: FLT1 L1CAM NRP1 PGF PLXNA1 PLXNB1 SEMA3B SEMA3C SEMA3F SEMA4F VEGFA	3 interacting genes: NRP1 NRP2 SGCE
Entrez ID		8828	10512
HPRD ID		03643	04034
Ensembl ID		ENSG00000118257	ENSG00000075223
Uniprot IDs		O60462 Q7Z3T9	Q99985
PDB IDs		2QQJ 2QQK 2QQL 2QQO 4QDQ 4QDR 4QDS 5DN2 5DQ0 6GH8 6TDB 6TJT
Enriched GO Terms of Interacting Partners?
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