PFKFB3 and PFKFB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PFKFB3	PFKFB1
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
	Molecular Function	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Binding Identical Protein Binding Fructose-6-phosphate Binding
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Brain Development Dephosphorylation Carbohydrate Phosphorylation	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Dephosphorylation Animal Organ Regeneration Response To Insulin Positive Regulation Of Glucokinase Activity Response To Glucagon Response To Starvation Carbohydrate Phosphorylation Response To Glucocorticoid Response To CAMP
Pathways		Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PKA-mediated phosphorylation of key metabolic factors PP2A-mediated dephosphorylation of key metabolic factors Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs			D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate sn-glycerol 3-phosphate Adenosine 5'-[gamma-thio]triphosphate Guanosine-5'-Triphosphate Fructose-6-phosphate
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31959851 31619474) Asthma (childhood onset) ( 31036433) Celiac disease ( 22057235 24999842) Crohn's disease ( 28067908) Latent autoimmune diabetes ( 30254083) Metabolite levels ( 23823483) Obesity (extreme) ( 31888951) Plasma anti-thyroid peroxidase levels ( 29678681) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Selective IgA deficiency ( 27723758) Western dietary pattern ( 28644415)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		4 interacting genes: GATA3 GCK PFKFB1 THAP1	15 interacting genes: AKT1 APP DDIT4L KATNBL1 PDE4A PFKFB3 PFKFB4 PLEKHG4 PRKACA PRKCA VWC2 ZNF276 ZNF474 ZNF655 ZNF688
Entrez ID		5209	5207
HPRD ID		05612	02411
Ensembl ID		ENSG00000170525	ENSG00000158571
Uniprot IDs		B7Z8A0 Q16875	I1Z9G4 P16118
PDB IDs		2AXN 2DWO 2DWP 2I1V 3QPU 3QPV 3QPW 4D4J 4D4K 4D4L 4D4M 4MA4 5AJV 5AJW 5AJX 5AJY 5AJZ 5AK0 6ETJ 6HVH 6HVI 6HVJ 6IBX 6IBY 6IBZ 6IC0	1K6M
Enriched GO Terms of Interacting Partners?
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