PFKFB3 and GATA3

		PFKFB3	GATA3
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	GATA binding protein 3
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Interleukin-2 Receptor Binding Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding E-box Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Brain Development Dephosphorylation Carbohydrate Phosphorylation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Neuron Migration Type IV Hypersensitivity Regulation Of Cytokine Production Kidney Development Mesonephros Development Lens Development In Camera-type Eye Immune System Development Pro-T Cell Differentiation Aortic Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Defense Response Humoral Immune Response Signal Transduction Axon Guidance Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Xenobiotic Stimulus Response To Virus Anatomical Structure Morphogenesis Post-embryonic Development Positive Regulation Of Signal Transduction Response To Gamma Radiation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Phosphatidylinositol 3-kinase Signaling T Cell Differentiation Erythrocyte Differentiation Regulation Of Epithelial Cell Differentiation TOR Signaling Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Embryonic Hemopoiesis Cellular Response To Interferon-alpha Ureter Maturation Parathyroid Hormone Secretion Norepinephrine Biosynthetic Process Inner Ear Morphogenesis Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Neuron Apoptotic Process Ear Development Response To Estrogen Thymic T Cell Selection T-helper 2 Cell Differentiation Innate Immune Response Cell Fate Commitment Response To Ethanol Positive Regulation Of T Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Sympathetic Nervous System Development Thymus Development Embryonic Organ Development Developmental Growth Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Kinase B Signaling Parathyroid Gland Development Pharyngeal System Development Uterus Development Mesenchymal To Epithelial Transition Mast Cell Differentiation Ureteric Bud Formation Regulation Of Histone H3-K27 Methylation Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Histone H3-K14 Acetylation Otic Vesicle Development Cellular Response To BMP Stimulus Positive Regulation Of Ureteric Bud Formation Nephric Duct Morphogenesis Nephric Duct Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Ureter Morphogenesis Lymphocyte Migration Cochlea Development Negative Regulation Of DNA Demethylation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Establishment Of Cell Polarity Negative Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Positive Regulation Of Thyroid Hormone Generation Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cellular Response To X-ray Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation
Pathways		Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31959851 31619474) Asthma (childhood onset) ( 31036433) Celiac disease ( 22057235 24999842) Crohn's disease ( 28067908) Latent autoimmune diabetes ( 30254083) Metabolite levels ( 23823483) Obesity (extreme) ( 31888951) Plasma anti-thyroid peroxidase levels ( 29678681) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Selective IgA deficiency ( 27723758) Western dietary pattern ( 28644415)	Acute lymphoblastic leukemia (adolescents and young adults) ( 25468567) Acute lymphoblastic leukemia (B-cell precursor) ( 29296818 23996088) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 31361310 31959851 30929738 34103634 27182965 32296059 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune traits (pleiotropy) ( 30572963) B cell acute lymphoblastic leukaemia (abnormal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B cell acute lymphoblastic leukaemia in adulthood ( 29296818) B cell acute lymphoblastic leukaemia in young adulthood ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Basal cell carcinoma ( 25855136 27539887) Benign prostatic hyperplasia and/or lower urinary tract symptoms ( 28656603) Calcium levels ( 24068962) Colorectal cancer ( 25990418 30529582 28869801 24737748 31826910) Colorectal cancer (diet interaction) ( 24743840) Colorectal cancer or advanced adenoma ( 30510241) Craniofacial microsomia ( 26853712) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Fasting glucose change (short-term) ( 31263163) General risk tolerance (MTAG) ( 30643258) Glycemic traits (pleiotropy) ( 31021400) Hair shape ( 29220522) Hodgkin's lymphoma ( 21037568 29196614 24920014) Intracranial aneurysm ( 29531279) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mild influenza (H1N1) infection ( 26379185) Multiple sclerosis ( 31604244) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Nodular sclerosis Hodgkin lymphoma ( 29196614) Obstetric antiphospholipid syndrome ( 28424481) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Plasma parathyroid hormone levels ( 30134803) Recalcitrant atopic dermatitis ( 25935106) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Scalp hair shape ( 26926045) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Smoking status (ever vs never smokers) ( 30643258) Stroke ( 26089329) Systemic lupus erythematosus ( 26502338) Takayasu arteritis ( 25604533) Thyroid stimulating hormone levels ( 30367059) Type 1 diabetes ( 34012112 31152121)
Interacting Genes		4 interacting genes: GATA3 GCK PFKFB1 THAP1	42 interacting genes: ACTN2 ATP5F1C CDK2 CYSRT1 ETS1 ETS2 FBXW7 GDI2 HACD1 HDAC1 HDAC2 HDAC3 HIF1A KDM1A KRTAP12-1 KRTAP13-2 KRTAP6-2 KRTAP6-3 LCK LMO1 LMO2 MAPK14 MED1 NET1 NUDT5 PFKFB3 PLEKHG4 PRKCQ PSMA3 RAD51C RARB REPIN1 SATB1 SP1 SPI1 STAP1 TAL1 TASOR2 TRIM55 TRIM63 UPF2 ZFPM2
Entrez ID		5209	2625
HPRD ID		05612	00572
Ensembl ID		ENSG00000170525	ENSG00000107485
Uniprot IDs		B7Z8A0 Q16875	P23771
PDB IDs		2AXN 2DWO 2DWP 2I1V 3QPU 3QPV 3QPW 4D4J 4D4K 4D4L 4D4M 4MA4 5AJV 5AJW 5AJX 5AJY 5AJZ 5AK0 6ETJ 6HVH 6HVI 6HVJ 6IBX 6IBY 6IBZ 6IC0	4HC7 4HC9 4HCA
Enriched GO Terms of Interacting Partners?
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