PEX6 and CERS2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		PEX6	CERS2
Description		peroxisomal biogenesis factor 6	ceramide synthase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Photoreceptor Cell Cilium	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding ATP Hydrolysis Activity Protein-containing Complex Binding	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Translocation Protein Stabilization	Regulation Of Lipid Metabolic Process Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration
Pathways		Peroxisomal protein import Peroxisomal protein import	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Alzheimer's disease in APOE e4+ carriers ( 25778476) Hematocrit ( 32888494) Red blood cell count ( 32888494)	Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971) Caffeine consumption from coffee or tea ( 33287642) Estimated glomerular filtration rate ( 31152163 31015462) Facial attractiveness (female raters) ( 30946739) Glycated hemoglobin levels ( 34059833 28898252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Reticulocyte fraction of red cells ( 27863252) Rhegmatogenous retinal detachment ( 23585552)
Interacting Genes		9 interacting genes: ATF7IP CERS2 NFKBIE PEX1 PEX26 PEX5 RPL27A RPS14 SMAD3	14 interacting genes: ASGR1 ASGR2 ATP6V0C DRD2 HSP90AA1 IER3IP1 NFE2L2 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6 TNFSF4 YIF1A
Entrez ID		5190	29956
HPRD ID		03293	06080
Ensembl ID		ENSG00000124587	ENSG00000143418
Uniprot IDs		A0A024RD09 Q13608	Q96G23
PDB IDs
Enriched GO Terms of Interacting Partners?
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